KRT2 and KRT16

Data Source:
BioGRID (two hybrid)

		KRT2	KRT16
Description		keratin 2	keratin 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Nucleus Cytosol Cytoskeleton Intermediate Filament Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Skin Epidermis	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Keratinocyte Development Epidermis Development Peptide Cross-linking Keratinization Keratinocyte Activation Keratinocyte Proliferation Intermediate Filament Organization Positive Regulation Of Epidermis Development Keratinocyte Migration Cornification	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Aging Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Keratinocyte Migration Establishment Of Skin Barrier Cornification
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs		Zinc Copper Anthralin Zinc acetate	Zinc Zinc acetate
Diseases		Ichthyosis bullosa of Siemens	Non-epidermolytic palmoplantar keratoderma (NEPPK) Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS
Interacting Genes		15 interacting genes: EVPL KRT13 KRT15 KRT16 KRT19 KRT25 KRT27 KRT31 KRT33B KRT35 KRT36 KRT38 KRT40 SIRPA SMAD3	56 interacting genes: AMOT ARFIP2 C1orf109 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 EPM2AIP1 GAS8 GNG10 HGS KIFC3 KLC4 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1
Entrez ID		3849	3868
HPRD ID		02560	01018
Ensembl ID		ENSG00000172867	ENSG00000186832
Uniprot IDs		P35908	P08779
PDB IDs
Enriched GO Terms of Interacting Partners?
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