DVL3 and KLHL12

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DVL3	KLHL12
Description		dishevelled segment polarity protein 3	kelch like family member 12
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GO Annotations	Cellular Component	Chromatin Cytosol	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Small GTPase Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Degradation of DVL
Drugs
Diseases
GWAS		Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)
Interacting Genes		164 interacting genes: ABT1 ADAP1 AKAP17A ANKRD36B AP3M1 AXIN1 BAHD1 BEND7 BHLHE40 C1orf35 C8orf33 CBX8 CCDC33 CCNK CCNL1 CDYL2 CEP57L1 CEP70 CEP76 CLK1 CSNK1D CSNK1E CSNK2A1 CT45A10 CT45A3 CTNNB1 CYSRT1 DAB2 DDX54 DIDO1 DPPA2 DVL1 EIF1B EIF3D ENKD1 FAM13C FAM90A1 FARS2 FGF16 FLACC1 GADD45GIP1 HOMER3 HOXA5 HOXC5 HOXC8 INO80B KAT7 KAZN KCTD10 KCTD7 KLF1 KLF15 KLF3 KLF4 KLHL12 LENG8 LNX1 LONRF1 LRRK2 LUZP4 LY6H MAB21L3 MAGEB4 MAGOHB MARK2 MATN2 NFYA NKD1 NOL12 NXF1 PATZ1 PHF19 PIK3CB PITX1 PLAGL2 PLN PNKP PPM1A PPP1R16B PPP2CA PRKAA2 PRPF18 PRPF3 PRPF31 PRPF38A PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSME3 PSMF1 RBM15B RBM39 RNF151 RPL11 RPS10 RRP8 RWDD2B SAP30L SHFL SNIP1 SNX22 SORBS3 STOM SUV39H1 SYT6 SYTL4 TBPL1 TCEA2 TCEANC TFG THAP7 TLE5 TNFAIP8L1 TNP1 TPTEP2-CSNK1E TRAF2 TRIM41 TRIM54 TSN TSPYL1 TSPYL6 UTP3 VANGL1 VAX1 WDR25 WT1 XPA YTHDC1 ZBTB24 ZBTB26 ZBTB47 ZBTB48 ZBTB8A ZFP57 ZNF165 ZNF2 ZNF264 ZNF319 ZNF408 ZNF417 ZNF441 ZNF444 ZNF497 ZNF512B ZNF552 ZNF581 ZNF648 ZNF696 ZNF697 ZNF699 ZNF71 ZNF764 ZNF774 ZNF775 ZNF792 ZNF821 ZNF837 ZRSR2 ZSCAN21 ZSCAN22 ZSCAN25	62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		1857	59349
HPRD ID		03222	13925
Ensembl ID		ENSG00000161202	ENSG00000117153
Uniprot IDs		Q92997 Q9UG07	Q53G59 Q9H7R2
PDB IDs		6V7O	2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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