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DVL3 and CEP70
Data Source:
BioGRID
(two hybrid)
DVL3
CEP70
Description
dishevelled segment polarity protein 3
centrosomal protein 70
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Cytosol
Centrosome
Cytosol
Molecular Function
Protease Binding
Signaling Receptor Binding
Frizzled Binding
Protein Binding
Beta-catenin Binding
Small GTPase Binding
Protein Binding
Identical Protein Binding
Gamma-tubulin Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Response To Drug
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Beta-catenin Destruction Complex Disassembly
G2/M Transition Of Mitotic Cell Cycle
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Microtubule Cytoskeleton Organization
Ciliary Basal Body-plasma Membrane Docking
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Diseases
GWAS
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Major depressive disorder (
22472876
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease (
29631575
)
Male-pattern baldness (
28196072
)
Interacting Genes
164 interacting genes:
ABT1
ADAP1
AKAP17A
ANKRD36B
AP3M1
AXIN1
BAHD1
BEND7
BHLHE40
C1orf35
C8orf33
CBX8
CCDC33
CCNK
CCNL1
CDYL2
CEP57L1
CEP70
CEP76
CLK1
CSNK1D
CSNK1E
CSNK2A1
CT45A10
CT45A3
CTNNB1
CYSRT1
DAB2
DDX54
DIDO1
DPPA2
DVL1
EIF1B
EIF3D
ENKD1
FAM13C
FAM90A1
FARS2
FGF16
FLACC1
GADD45GIP1
HOMER3
HOXA5
HOXC5
HOXC8
INO80B
KAT7
KAZN
KCTD10
KCTD7
KLF1
KLF15
KLF3
KLF4
KLHL12
LENG8
LNX1
LONRF1
LRRK2
LUZP4
LY6H
MAB21L3
MAGEB4
MAGOHB
MARK2
MATN2
NFYA
NKD1
NOL12
NXF1
PATZ1
PHF19
PIK3CB
PITX1
PLAGL2
PLN
PNKP
PPM1A
PPP1R16B
PPP2CA
PRKAA2
PRPF18
PRPF3
PRPF31
PRPF38A
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSME3
PSMF1
RBM15B
RBM39
RNF151
RPL11
RPS10
RRP8
RWDD2B
SAP30L
SHFL
SNIP1
SNX22
SORBS3
STOM
SUV39H1
SYT6
SYTL4
TBPL1
TCEA2
TCEANC
TFG
THAP7
TLE5
TNFAIP8L1
TNP1
TPTEP2-CSNK1E
TRAF2
TRIM41
TRIM54
TSN
TSPYL1
TSPYL6
UTP3
VANGL1
VAX1
WDR25
WT1
XPA
YTHDC1
ZBTB24
ZBTB26
ZBTB47
ZBTB48
ZBTB8A
ZFP57
ZNF165
ZNF2
ZNF264
ZNF319
ZNF408
ZNF417
ZNF441
ZNF444
ZNF497
ZNF512B
ZNF552
ZNF581
ZNF648
ZNF696
ZNF697
ZNF699
ZNF71
ZNF764
ZNF774
ZNF775
ZNF792
ZNF821
ZNF837
ZRSR2
ZSCAN21
ZSCAN22
ZSCAN25
242 interacting genes:
ABT1
AGBL2
AKAP17A
ARHGEF3
ARMCX1
ATP5PO
ATXN7
BARD1
BAZ2B
BEX2
BRD1
BRMS1
BRMS1L
BRPF1
BYSL
C1orf35
C7orf25
C8orf33
CARD9
CAVIN3
CBX8
CCDC187
CCDC85B
CDC37
CDC73
CDCA7L
CEP57L1
CFAP53
CLPB
COIL
CWF19L2
DAXX
DAZAP2
DDX41
DDX6
DNAJB11
DNTTIP2
DVL3
EAF1
EBNA1BP2
EIF3D
ELOA
ELOA2
EMD
EMP1
ENKD1
ERCC3
FAM118B
FAM124A
FAM133A
FAM13C
FAM161A
FAM161B
FAM214B
FAM90A1
GADD45GIP1
GAS8
GATAD2B
GCC1
GEM
GLYCTK
GPATCH2L
GPATCH4
GPX7
GSE1
HAUS1
HDAC4
HDAC6
HIC2
HMGB4
HOXB5
HOXC8
HSPD1
IK
INO80B
INPP5J
IPCEF1
IQCE
IQUB
ITPKB
KANK2
KANSL1
KAT14
KAT5
KAT7
KDM1A
KRI1
KRT31
LAMTOR5
LCOR
LENG1
LENG8
LIN37
LNX1
MAB21L2
MAGOH
MBD3
MCM10
MCRS1
MEST
METTL17
MFAP1
MKRN3
MRPL44
NEBL
NIPSNAP3A
NKAP
NKAPD1
NOL12
NOP2
NOP53
NOXA1
NRIP1
NTAQ1
NUSAP1
ODAD4
PAM16
PIBF1
PIMREG
PKN1
PLA2G2A
PPFIA1
PPIG
PPP1R16B
PPP1R18
PRKRIP1
PRPF18
PRPF3
PRPF31
PSMA1
PSORS1C2
RASSF10
RBM10
RCOR3
RHPN1
RNF169
RNF6
RPL13
SCNM1
SEC14L1
SERPINH1
SETD5
SFR1
SH2D4A
SLU7
SMARCE1
SNRPD2
SNW1
SOD2
SPANXN3
SRGN
SSX3
STK25
STMN2
SUV39H1
SUV39H2
SYT17
SYTL4
SYTL5
TAF1D
TBC1D22B
TBC1D30
TCAF1
TCEANC
TEAD4
TLK2
TRAF3IP3
TRIM29
TRIM3
TRIM42
TSFM
TSGA10IP
TSHZ3
TTLL10
TXLNB
TXN2
USP2
UTP11
UTP14A
UTP14C
UTP25
UTP3
VXN
WT1
YJU2
ZBTB16
ZBTB24
ZBTB4
ZBTB47
ZBTB48
ZBTB49
ZBTB8A
ZCCHC10
ZFC3H1
ZFHX3
ZFP1
ZFP91
ZGPAT
ZNF136
ZNF140
ZNF148
ZNF165
ZNF169
ZNF17
ZNF20
ZNF202
ZNF227
ZNF239
ZNF264
ZNF266
ZNF302
ZNF329
ZNF35
ZNF366
ZNF408
ZNF410
ZNF417
ZNF426
ZNF433
ZNF439
ZNF490
ZNF491
ZNF555
ZNF557
ZNF572
ZNF574
ZNF578
ZNF587
ZNF599
ZNF607
ZNF648
ZNF669
ZNF688
ZNF696
ZNF775
ZNF777
ZNF785
ZNF835
ZNF860
ZSCAN12
ZSCAN21
ZSCAN23
Entrez ID
1857
80321
HPRD ID
03222
16779
Ensembl ID
ENSG00000161202
ENSG00000114107
Uniprot IDs
Q92997
Q9UG07
A0A140VJG2
B7Z2D2
Q8NHQ1
PDB IDs
6V7O
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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