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DVL3 and PLN
Data Source:
BioGRID
(two hybrid)
DVL3
PLN
Description
dishevelled segment polarity protein 3
phospholamban
Image
GO Annotations
Cellular Component
Chromatin
Cytosol
Mitochondrion
Endoplasmic Reticulum
Membrane
Mitochondrial Membrane
Vesicle
Sarcoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Calcium Ion-transporting ATPase Complex
Molecular Function
Protease Binding
Signaling Receptor Binding
Frizzled Binding
Protein Binding
Beta-catenin Binding
Small GTPase Binding
Enzyme Inhibitor Activity
Protein Binding
ATPase Inhibitor Activity
Identical Protein Binding
Protein Homodimerization Activity
ATPase Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Response To Drug
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Beta-catenin Destruction Complex Disassembly
Regulation Of The Force Of Heart Contraction
Calcium Ion Transport
Notch Signaling Pathway
Blood Circulation
Regulation Of Heart Contraction
Response To Zinc Ion
Negative Regulation Of Heart Rate
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Negative Regulation Of ATPase Activity
Response To Insulin
Response To Testosterone
Negative Regulation Of Catalytic Activity
Cardiac Muscle Tissue Development
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Calcium Ion Transport
Negative Regulation Of Calcium Ion Transport
Relaxation Of Cardiac Muscle
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Binding
Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Regulation Of Relaxation Of Cardiac Muscle
Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Ion homeostasis
Ion transport by P-type ATPases
Drugs
Diseases
GWAS
Facial morphology traits (63 three-dimensional facial segments) (
29459680
)
Major depressive disorder (
22472876
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Atrial fibrillation (
28416818
30061737
)
Cardiac structure and function (
19584346
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
27659466
)
QT interval (
23166209
24952745
19305408
19305409
19587794
29874175
)
Resting heart rate (
27798624
)
Interacting Genes
164 interacting genes:
ABT1
ADAP1
AKAP17A
ANKRD36B
AP3M1
AXIN1
BAHD1
BEND7
BHLHE40
C1orf35
C8orf33
CBX8
CCDC33
CCNK
CCNL1
CDYL2
CEP57L1
CEP70
CEP76
CLK1
CSNK1D
CSNK1E
CSNK2A1
CT45A10
CT45A3
CTNNB1
CYSRT1
DAB2
DDX54
DIDO1
DPPA2
DVL1
EIF1B
EIF3D
ENKD1
FAM13C
FAM90A1
FARS2
FGF16
FLACC1
GADD45GIP1
HOMER3
HOXA5
HOXC5
HOXC8
INO80B
KAT7
KAZN
KCTD10
KCTD7
KLF1
KLF15
KLF3
KLF4
KLHL12
LENG8
LNX1
LONRF1
LRRK2
LUZP4
LY6H
MAB21L3
MAGEB4
MAGOHB
MARK2
MATN2
NFYA
NKD1
NOL12
NXF1
PATZ1
PHF19
PIK3CB
PITX1
PLAGL2
PLN
PNKP
PPM1A
PPP1R16B
PPP2CA
PRKAA2
PRPF18
PRPF3
PRPF31
PRPF38A
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSME3
PSMF1
RBM15B
RBM39
RNF151
RPL11
RPS10
RRP8
RWDD2B
SAP30L
SHFL
SNIP1
SNX22
SORBS3
STOM
SUV39H1
SYT6
SYTL4
TBPL1
TCEA2
TCEANC
TFG
THAP7
TLE5
TNFAIP8L1
TNP1
TPTEP2-CSNK1E
TRAF2
TRIM41
TRIM54
TSN
TSPYL1
TSPYL6
UTP3
VANGL1
VAX1
WDR25
WT1
XPA
YTHDC1
ZBTB24
ZBTB26
ZBTB47
ZBTB48
ZBTB8A
ZFP57
ZNF165
ZNF2
ZNF264
ZNF319
ZNF408
ZNF417
ZNF441
ZNF444
ZNF497
ZNF512B
ZNF552
ZNF581
ZNF648
ZNF696
ZNF697
ZNF699
ZNF71
ZNF764
ZNF774
ZNF775
ZNF792
ZNF821
ZNF837
ZRSR2
ZSCAN21
ZSCAN22
ZSCAN25
64 interacting genes:
ARL13B
ASGR2
ATP2A1
ATP2A2
ATP6V0E1
BCL2L13
BIK
CD53
CLDN7
CLEC2D
CPLX4
CREB3
CREB3L1
DMPK
DVL3
EDA
ELOVL4
FAM209A
FKBP8
FNDC9
GJA8
GPR152
GPR37L1
GPX8
HIBADH
HSD17B13
KIR2DL3
LDLRAD1
LSMEM2
MFF
MFSD5
MGST2
MGST3
MS4A7
MTIF3
MUC1
PLPPR1
PPP1R3A
PRKACA
RTN3
S100A1
SAR1A
SDC3
SIT1
SLC14A2
SLC30A8
SLC34A2
SLC35C2
SLC39A2
SLN
SPACA1
SPAG4
STX1A
STX2
TMEM106C
TMEM179B
TMEM205
TMEM31
TMEM45A
TMEM45B
TMEM52B
TMEM79
TMEM86B
TMPRSS2
Entrez ID
1857
5350
HPRD ID
03222
01395
Ensembl ID
ENSG00000161202
ENSG00000198523
Uniprot IDs
Q92997
Q9UG07
P26678
Q5R352
PDB IDs
6V7O
1K9N
1KCH
1PLN
1PLP
1PSL
1ZLL
2HYN
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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