KLHL12 and PLEKHA4

Data Source:
BioGRID (two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology)

		KLHL12	PLEKHA4
Description		kelch like family member 12	pleckstrin homology domain containing A4
Image
GO Annotations	Cellular Component	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway	Phosphatidylinositol Biosynthetic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Degradation of DVL	Synthesis of PIPs at the plasma membrane
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS			High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4	8 interacting genes: ABL1 CCNG1 EEF1G KAT5 KLHL12 LRIF1 MEI4 SETDB1
Entrez ID		59349	57664
HPRD ID		13925	09683
Ensembl ID		ENSG00000117153	ENSG00000105559
Uniprot IDs		Q53G59 Q9H7R2	Q9H4M7
PDB IDs		2VPJ 6TTK 6V7O	1UPQ 1UPR
Enriched GO Terms of Interacting Partners?
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