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SH2B2 and AKT1
Data Source:
HPRD
(in vitro, in vivo)
SH2B2
AKT1
Description
SH2B adaptor protein 2
AKT serine/threonine kinase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Spindle
Cytosol
Plasma Membrane
Cell-cell Junction
Microtubule Cytoskeleton
Lamellipodium
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Vesicle
Protein-containing Complex
Ciliary Basal Body
Postsynapse
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
Calmodulin Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Kinase Activity
Enzyme Binding
Nitric-oxide Synthase Regulator Activity
GTPase Activating Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Phosphatidylinositol-3,4-bisphosphate Binding
Protein Phosphatase 2A Binding
14-3-3 Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Blood Coagulation
Insulin Receptor Signaling Pathway
Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
B Cell Receptor Signaling Pathway
Osteoblast Differentiation
Maternal Placenta Development
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Sphingosine-1-phosphate Receptor Signaling Pathway
Glycogen Biosynthetic Process
Regulation Of Glycogen Biosynthetic Process
Glucose Metabolic Process
Translation
Regulation Of Translation
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Nitric Oxide Biosynthetic Process
Activation-induced Cell Death Of T Cells
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Germ Cell Development
Aging
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Apoptotic Mitochondrial Changes
Carbohydrate Transport
Response To Heat
Negative Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Fibroblast Migration
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Sodium Ion Transport
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Endopeptidase Activity
Regulation Of Neuron Projection Development
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Macroautophagy
Phosphorylation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cytokine-mediated Signaling Pathway
Spinal Cord Development
Cell Projection Organization
Cell Differentiation
Protein Catabolic Process
Hyaluronan Metabolic Process
Positive Regulation Of Cell Growth
Regulation Of Cell Migration
Endocrine Pancreas Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Regulation Of Myelination
Lipopolysaccharide-mediated Signaling Pathway
TOR Signaling
Negative Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Response To Food
Activation Of Protein Kinase B Activity
Positive Regulation Of Cellular Protein Metabolic Process
Peripheral Nervous System Myelin Maintenance
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Cellular Response To Vascular Endothelial Growth Factor Stimulus
NIK/NF-kappaB Signaling
Glucose Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Anoikis
Regulation Of MRNA Stability
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Cell Size
Negative Regulation Of Proteolysis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Negative Regulation Of JNK Cascade
Positive Regulation Of Organ Growth
Protein Autophosphorylation
Positive Regulation Of Lipid Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Striated Muscle Cell Differentiation
Negative Regulation Of Protein Kinase B Signaling
Excitatory Postsynaptic Potential
Response To Growth Hormone
Mammary Gland Epithelial Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Response To UV-A
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Organic Cyclic Compound
Cellular Response To Hypoxia
Negative Regulation Of Protein Serine/threonine Kinase Activity
Establishment Of Protein Localization To Mitochondrion
Maintenance Of Protein Location In Mitochondrion
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Protein Kinase Activity By Protein Phosphorylation
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of I-kappaB Phosphorylation
Cellular Response To Nerve Growth Factor Stimulus
Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Lymphocyte Migration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Regulation of KIT signaling
Factors involved in megakaryocyte development and platelet production
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
MTOR signalling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
Extra-nuclear estrogen signaling
Negative regulation of NOTCH4 signaling
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
ATP
Arsenic trioxide
Genistein
Inositol 1,3,4,5-Tetrakisphosphate
Resveratrol
Archexin
Enzastaurin
Perifosine
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases
PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
GWAS
Type 2 diabetes (
31049640
)
Apolipoprotein A1 levels (
32203549
)
Endometrial cancer (
27135401
)
Endometrial endometrioid carcinoma (
27135401
)
HDL cholesterol (
24097068
30275531
25961943
)
HDL cholesterol levels (
32203549
28334899
)
Neutrophil count (
32888494
)
Interacting Genes
42 interacting genes:
AKT1
ASB6
BTK
CBL
CLK1
CLK3
DUSP13
EGFR
EPOR
ERBB2
ERBB4
FAM124B
FAM90A1
FYN
GRB2
HCK
IL36RN
INSR
JAK1
JAK2
JAK3
KIT
LMO3
LYN
MAGEH1
MCRS1
MET
MTDH
NTRK1
NTRK2
PDLIM7
PLEKHA3
RAB6B
SH2B1
SHC1
SORBS1
SYK
TLE5
TLNRD1
USP2
ZNF414
ZNF417
319 interacting genes:
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
APLP2
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARNT
ATXN1
AURKA
BABAM1
BAD
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BEX1
BLVRA
BPGM
BRAF
BRCA1
BUB1
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CD44
CDC37
CDH1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CNOT9
CREB1
CREBBP
CSNK2A1
CTDSP2
CTNNA1
CTNNB1
CYLD
DAB2IP
DCTN1
DDIT4L
DLC1
DNAJB1
DNMT1
EEF1G
EIF4EBP1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FANCA
FANCI
FASN
FBXO31
FBXW7
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FZR1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ITGB3
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK14
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MATK
MDM2
MDM4
MESD
METTL1
MLH3
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCOA4
NCOR2
NF1
NF2
NGB
NOL4
NOS3
NOTCH1
NR4A1
NRAS
NSD3
OSGIN1
PAK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PMS2
PPARGC1B
PPL
PPM1A
PPP2CA
PPP2R1A
PRG2
PRKCQ
PRKCZ
PRKDC
PSMC5
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYGO2
RAB3D
RAC1
RAF1
RARA
RASL10B
RASSF1
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
S100A14
S1PR1
SERPINB5
SETDB1
SH2B2
SH3RF1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS2
SOX2
SOX4
SP1
SP3
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TLR2
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRIB3
TRIM13
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
USP4
UXS1
VEGFA
VHL
VIM
WNK1
WNK4
XAF1
XIAP
YAP1
YBX1
YWHAZ
ZFP36L1
ZHX1
ZNF691
ZRANB1
Entrez ID
10603
207
HPRD ID
16097
01261
Ensembl ID
ENSG00000160999
ENSG00000142208
Uniprot IDs
O14492
B0LPE5
B3KVH4
P31749
PDB IDs
1Q2H
1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
Enriched GO Terms of Interacting Partners
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