SH2B2 and ASB6

		SH2B2	ASB6
Description		SH2B adaptor protein 2	ankyrin repeat and SOCS box containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Protein Binding
	Biological Process	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway	Protein Ubiquitination Intracellular Signal Transduction Post-translational Protein Modification
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	16 interacting genes: APP CHRNB1 DUSP23 FAM9B HOMEZ HOXB5 L3MBTL3 MOS POLR2A RNF41 SH2B2 TARS2 TCAP ZBTB42 ZNF587 ZNF655
Entrez ID		10603	140459
HPRD ID		16097	10673
Ensembl ID		ENSG00000160999	ENSG00000148331
Uniprot IDs		O14492	F6TX30 Q9NWX5
PDB IDs		1Q2H
Enriched GO Terms of Interacting Partners?
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