SH2B2 and ZNF414

Data Source:
BioGRID (two hybrid)

		SH2B2	ZNF414
Description		SH2B adaptor protein 2	zinc finger protein 414
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Chromatin Nucleus
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway	Regulation Of Transcription By RNA Polymerase II
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	54 interacting genes: ADAMTSL4 CALCOCO2 CARD10 CFP CNFN CYSRT1 FBLN2 GOLGA2 GOLGA6L9 HOMER3 ITIH6 KANK2 KRT31 KRT34 KRT36 KRT86 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP13-3 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP4-12 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-3 MDFI MGAT5B MKRN3 MTUS2 NBPF19 NOTCH2NLA PDE4DIP PICK1 POU2AF1 PPP1R16A RBCK1 RBM11 RNF125 SH2B2 SORBS3 SPRED2 TERF2IP TEX11 TLE5 TRIM10 TRIM27 TRIM42 WWOX ZMYND12
Entrez ID		10603	84330
HPRD ID		16097	17511
Ensembl ID		ENSG00000160999	ENSG00000133250
Uniprot IDs		O14492	Q96IQ9
PDB IDs		1Q2H
Enriched GO Terms of Interacting Partners?
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