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SH2B2 and MCRS1
Data Source:
BioGRID
(two hybrid)
SH2B2
MCRS1
Description
SH2B adaptor protein 2
microspherule protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Polysome
Dendrite
Ino80 Complex
Perikaryon
NSL Complex
MLL1 Complex
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Signaling Adaptor Activity
SH2 Domain Binding
G-quadruplex RNA Binding
Protein Binding
Poly(U) RNA Binding
Poly(G) Binding
Biological Process
Blood Coagulation
Insulin Receptor Signaling Pathway
Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
B Cell Receptor Signaling Pathway
DNA Repair
DNA Recombination
Cellular Protein Modification Process
Viral Process
Protein Deubiquitination
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleolus
Pathways
Regulation of KIT signaling
Factors involved in megakaryocyte development and platelet production
HATs acetylate histones
UCH proteinases
DNA Damage Recognition in GG-NER
Drugs
Diseases
GWAS
Type 2 diabetes (
31049640
)
Interacting Genes
42 interacting genes:
AKT1
ASB6
BTK
CBL
CLK1
CLK3
DUSP13
EGFR
EPOR
ERBB2
ERBB4
FAM124B
FAM90A1
FYN
GRB2
HCK
IL36RN
INSR
JAK1
JAK2
JAK3
KIT
LMO3
LYN
MAGEH1
MCRS1
MET
MTDH
NTRK1
NTRK2
PDLIM7
PLEKHA3
RAB6B
SH2B1
SHC1
SORBS1
SYK
TLE5
TLNRD1
USP2
ZNF414
ZNF417
126 interacting genes:
AGGF1
AXIN2
BACH2
BEND3
BHLHA9
BHLHE40
BLM
BRD8
BRMS1
BRMS1L
C18orf25
C2CD6
C7orf57
C8orf34
CARD9
CAVIN2
CBY2
CCDC13
CCDC136
CCDC85B
CCHCR1
CCNH
CDCA7L
CEP44
CEP70
CNTROB
COIL
CREB3L3
CSRNP1
CYSRT1
CYTIP
DAXX
DRAP1
DVL2
EGR2
ERF
EVI5
FAM9A
FNDC8
FSD2
FXR1
FXR2
GAS7
GCC1
GEM
GIGYF1
GOLGA2
GPBP1
HMBOX1
HOOK2
IKZF1
IKZF3
IKZF4
INO80E
INSYN1
JAKMIP1
KANK2
KAT7
KDM1A
KIAA1958
KRT35
KRTAP10-7
KRTAP2-3
KRTAP2-4
KXD1
LIG4
LSM6
LZTS1
MAGEA11
MAGEA6
MAPK9
MED4
MEOX1
MFAP1
MIER2
MIER3
NAA10
NAB2
NKAPD1
NOP2
OSBPL3
PBK
PBX2
PCM1
PHC2
PIBF1
PINX1
PKNOX2
PPP1R13B
PRMT5
PSTPIP1
PTEN
RABEP1
RALYL
RARA
RETREG3
RIPPLY3
SH2B2
SNAPC5
SP4
SRRM4
SSMEM1
SUV39H1
TADA2B
TBC1D1
TERT
TFAP4
TLE5
TNIP1
TNNI1
TP63
TRIM37
TRIM41
TSPYL2
UPF3B
USHBP1
WASHC3
WBP11
XIAP
ZBTB22
ZCCHC10
ZCCHC12
ZNF23
ZNF639
ZNF8
ZRANB1
Entrez ID
10603
10445
HPRD ID
16097
11298
Ensembl ID
ENSG00000160999
ENSG00000187778
Uniprot IDs
O14492
A0A024R134
Q96EZ8
PDB IDs
1Q2H
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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