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SH2B2 and NTRK2
Data Source:
HPRD
(in vivo, in vitro)
SH2B2
NTRK2
Description
SH2B adaptor protein 2
neurotrophic receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Golgi Membrane
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Postsynaptic Density
Axon
Dendrite
Early Endosome Membrane
Terminal Bouton
Dendritic Spine
Receptor Complex
Axon Terminus
Perinuclear Region Of Cytoplasm
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protease Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Neurotrophin Receptor Activity
Protein Binding
ATP Binding
Protein Homodimerization Activity
Neurotrophin Binding
Brain-derived Neurotrophic Factor Binding
Brain-derived Neurotrophic Factor-activated Receptor Activity
Biological Process
Blood Coagulation
Insulin Receptor Signaling Pathway
Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
B Cell Receptor Signaling Pathway
Vasculogenesis
Neuron Migration
Positive Regulation Of Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Phospholipase C Activity
Multicellular Organism Development
Learning
Circadian Rhythm
Feeding Behavior
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Glutamate Secretion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuronal Action Potential Propagation
Central Nervous System Neuron Development
Cerebral Cortex Development
Myelination In Peripheral Nervous System
Neuron Differentiation
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Kinase Activity
Mechanoreceptor Differentiation
Regulation Of GTPase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Retinal Rod Cell Development
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Oligodendrocyte Differentiation
Peripheral Nervous System Neuron Development
Positive Regulation Of Axonogenesis
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synapse Assembly
Long-term Synaptic Potentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Amino Acid Stimulus
Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Anoikis
Pathways
Regulation of KIT signaling
Factors involved in megakaryocyte development and platelet production
NGF-independant TRKA activation
BDNF activates NTRK2 (TRKB) signaling
NTF3 activates NTRK2 (TRKB) signaling
NTF4 activates NTRK2 (TRKB) signaling
Activated NTRK2 signals through RAS
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
NTRK2 activates RAC1
NTRK2 activates RAC1
Activated NTRK2 signals through CDK5
Drugs
Amitriptyline
Esketamine
Entrectinib
Fostamatinib
Larotrectinib
Diseases
Neuroblastoma
GWAS
Type 2 diabetes (
31049640
)
Birth weight (
24950379
)
Body mass index (
28892062
25760438
)
Body size at age 10 (
32376654
)
Gout (normal type) (
32238385
)
Lifetime anxiety disorder (
31748690
)
Menarche (age at onset) (
25231870
)
Parkinson's disease progression (cognitive) (
33111402
)
Refractive error (
32231278
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Type 2 diabetes (
31118516
)
Waist-to-hip circumference ratio (recreational physical activity interaction) (
23192594
)
Interacting Genes
42 interacting genes:
AKT1
ASB6
BTK
CBL
CLK1
CLK3
DUSP13
EGFR
EPOR
ERBB2
ERBB4
FAM124B
FAM90A1
FYN
GRB2
HCK
IL36RN
INSR
JAK1
JAK2
JAK3
KIT
LMO3
LYN
MAGEH1
MCRS1
MET
MTDH
NTRK1
NTRK2
PDLIM7
PLEKHA3
RAB6B
SH2B1
SHC1
SORBS1
SYK
TLE5
TLNRD1
USP2
ZNF414
ZNF417
34 interacting genes:
AP1B1
BDNF
DOK5
DYNLL1
EGFR
ERBB2
ERBB4
FRS2
FRS3
FYN
GIPC1
KIDINS220
NCK1
NCK2
NDFIP1
NGFR
NMNAT1
NTF3
NTF4
PIK3R1
PLCG1
POLR2G
PTPN1
PTPN11
RASGRF1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TRAF6
UBB
Entrez ID
10603
4915
HPRD ID
16097
02712
Ensembl ID
ENSG00000160999
ENSG00000148053
Uniprot IDs
O14492
A0A024R230
Q16620
Q548C2
Q5VWE5
PDB IDs
1Q2H
1HCF
1WWB
2MFQ
4ASZ
4AT3
4AT4
4AT5
5MO9
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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