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SH2B2 and NTRK1
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro)
SH2B2
NTRK1
Description
SH2B adaptor protein 2
neurotrophic receptor tyrosine kinase 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Golgi Membrane
Early Endosome
Late Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endosome Membrane
Axon
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Protein-containing Complex
Neuronal Cell Body
Receptor Complex
Recycling Endosome Membrane
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
GPI-linked Ephrin Receptor Activity
Neurotrophin Receptor Activity
Neurotrophin P75 Receptor Binding
Protein Binding
ATP Binding
Nerve Growth Factor Receptor Activity
Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
Blood Coagulation
Insulin Receptor Signaling Pathway
Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
B Cell Receptor Signaling Pathway
Activation Of MAPKK Activity
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Aging
Learning Or Memory
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Response To Radiation
Programmed Cell Death Involved In Cell Development
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Olfactory Nerve Development
B Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Kinase Activity
Peptidyl-tyrosine Autophosphorylation
Nerve Growth Factor Signaling Pathway
Mechanoreceptor Differentiation
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Ras Protein Signal Transduction
Protein Autophosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Sympathetic Nervous System Development
Response To Axon Injury
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To Hydrostatic Pressure
Response To Electrical Stimulus
Regulation Of Protein Kinase B Signaling
Positive Regulation Of Synapse Assembly
Positive Regulation Of Synaptic Transmission, Glutamatergic
Sertoli Cell Development
Axonogenesis Involved In Innervation
Behavioral Response To Formalin Induced Pain
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Nicotine
Cellular Response To Amyloid-beta
Cellular Response To Nerve Growth Factor Stimulus
Pathways
Regulation of KIT signaling
Factors involved in megakaryocyte development and platelet production
PLC-gamma1 signalling
Signalling to RAS
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
NGF-independant TRKA activation
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
Drugs
Amitriptyline
Imatinib
Regorafenib
Entrectinib
Fostamatinib
Cenegermin
Larotrectinib
Pralsetinib
Diseases
Neuroblastoma
Thyroid cancer
GWAS
Type 2 diabetes (
31049640
)
Red cell distribution width (
32888494
)
Interacting Genes
42 interacting genes:
AKT1
ASB6
BTK
CBL
CLK1
CLK3
DUSP13
EGFR
EPOR
ERBB2
ERBB4
FAM124B
FAM90A1
FYN
GRB2
HCK
IL36RN
INSR
JAK1
JAK2
JAK3
KIT
LMO3
LYN
MAGEH1
MCRS1
MET
MTDH
NTRK1
NTRK2
PDLIM7
PLEKHA3
RAB6B
SH2B1
SHC1
SORBS1
SYK
TLE5
TLNRD1
USP2
ZNF414
ZNF417
40 interacting genes:
ABL1
ARHGAP32
CAV1
CRK
DNAJA3
DYNLL1
ERBB2
FRS2
FRS3
GIPC1
GRB2
IRS1
IRS2
KIDINS220
MAPK3
MATK
NEDD4L
NGF
NGFR
NTF3
PIK3R1
PLCG1
PTPN1
PTPN11
PTPRR
RAP1A
RASA1
RASGRF1
RUSC1
SH2B1
SH2B2
SHC1
SHC2
SHC3
SORT1
SQSTM1
TPTE
TRAF4
TRAF6
UBB
Entrez ID
10603
4914
HPRD ID
16097
01869
Ensembl ID
ENSG00000160999
ENSG00000198400
Uniprot IDs
O14492
P04629
X5DR71
PDB IDs
1Q2H
1HE7
1SHC
1WWA
1WWW
2IFG
2N90
4AOJ
4CRP
4F0I
4GT5
4PMM
4PMP
4PMS
4PMT
4YNE
4YPS
5H3Q
5I8A
5JFS
5JFV
5JFW
5JFX
5KMI
5KMJ
5KMK
5KML
5KMM
5KMN
5KMO
5KVT
5WR7
6D1Y
6D1Z
6D20
6D22
6DKB
6DKG
6DKI
6DKW
6IQN
6J5L
6NPT
6NSP
6NSS
6PL1
6PL2
6PL3
6PL4
6PMA
6PMB
6PMC
6PME
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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