AKT1 and PPP2CA

Data Source:
HPRD (in vivo, in vitro)

		AKT1	PPP2CA
Description		AKT serine/threonine kinase 1	protein phosphatase 2 catalytic subunit alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Plasma Membrane Cell-cell Junction Microtubule Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase C Binding Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Enzyme Binding Nitric-oxide Synthase Regulator Activity GTPase Activating Protein Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Phosphatase 2A Binding 14-3-3 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Translation Regulation Of Translation Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Activation-induced Cell Death Of T Cells Inflammatory Response Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Germ Cell Development Aging Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Carbohydrate Transport Response To Heat Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fibroblast Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Macroautophagy Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Spinal Cord Development Cell Projection Organization Cell Differentiation Protein Catabolic Process Hyaluronan Metabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Endocrine Pancreas Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Cellular Protein Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus NIK/NF-kappaB Signaling Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Anoikis Regulation Of MRNA Stability Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Cell Size Negative Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Negative Regulation Of JNK Cascade Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Striated Muscle Cell Differentiation Negative Regulation Of Protein Kinase B Signaling Excitatory Postsynaptic Potential Response To Growth Hormone Mammary Gland Epithelial Cell Differentiation Labyrinthine Layer Blood Vessel Development Response To UV-A Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Negative Regulation Of Protein Kinase Activity By Protein Phosphorylation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of I-kappaB Phosphorylation Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Regulation Of Protein Phosphorylation Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Mitotic Nuclear Envelope Reassembly Mesoderm Development RNA Splicing Response To Organic Substance Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Peptidyl-threonine Dephosphorylation Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation Meiotic Cell Cycle Peptidyl-serine Dephosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Microtubule Binding Positive Regulation Of Microtubule Binding
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases		PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) HDL cholesterol ( 24097068 30275531 25961943) HDL cholesterol levels ( 32203549 28334899) Neutrophil count ( 32888494)
Interacting Genes		319 interacting genes: ACAP1 ACAT2 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF APLP2 APOH APP APPL1 AR ARAF ARFIP2 ARNT ATXN1 AURKA BABAM1 BAD BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BUB1 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CD44 CDC37 CDH1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CHEK1 CHUK CLASP2 CLIP3 CLK2 CNOT9 CREB1 CREBBP CSNK2A1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS FZR1 GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MATK MDM2 MDM4 MESD METTL1 MLH3 MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCOA4 NCOR2 NF1 NF2 NGB NOL4 NOS3 NOTCH1 NR4A1 NRAS NSD3 OSGIN1 PAK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 PPARGC1B PPL PPM1A PPP2CA PPP2R1A PRG2 PRKCQ PRKCZ PRKDC PSMC5 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYGO2 RAB3D RAC1 RAF1 RARA RASL10B RASSF1 RGCC RHEBL1 RNF11 RNF115 RPS6KB1 S100A14 S1PR1 SERPINB5 SETDB1 SH2B2 SH3RF1 SIRPA SIRT1 SIRT6 SKI SKP2 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS2 SOX2 SOX4 SP1 SP3 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRIB3 TRIM13 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 USP4 UXS1 VEGFA VHL VIM WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1 ZNF691 ZRANB1	96 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 VAC14 VDR XRN1 YPEL3
Entrez ID		207	5515
HPRD ID		01261	08912
Ensembl ID		ENSG00000142208	ENSG00000113575
Uniprot IDs		B0LPE5 B3KVH4 P31749	B3KUN1 P67775
PDB IDs		1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X	2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 5W0W 6NTS
Enriched GO Terms of Interacting Partners?
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