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SH2B2 and PDLIM7
Data Source:
HPRD
(two hybrid, in vivo)
SH2B2
PDLIM7
Description
SH2B adaptor protein 2
PDZ and LIM domain 7
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Stress Fiber
Ruffle
Nucleoplasm
Cytosol
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Z Disc
Filamentous Actin
Molecular Function
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Signaling Adaptor Activity
SH2 Domain Binding
Actin Binding
Protein Binding
Metal Ion Binding
Muscle Alpha-actinin Binding
Biological Process
Blood Coagulation
Insulin Receptor Signaling Pathway
Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
B Cell Receptor Signaling Pathway
Ossification
Receptor-mediated Endocytosis
Axon Guidance
Heart Development
Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Differentiation
Muscle Structure Development
Pathways
Regulation of KIT signaling
Factors involved in megakaryocyte development and platelet production
RET signaling
Drugs
Diseases
GWAS
Type 2 diabetes (
31049640
)
Coronary artery disease (
29212778
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
42 interacting genes:
AKT1
ASB6
BTK
CBL
CLK1
CLK3
DUSP13
EGFR
EPOR
ERBB2
ERBB4
FAM124B
FAM90A1
FYN
GRB2
HCK
IL36RN
INSR
JAK1
JAK2
JAK3
KIT
LMO3
LYN
MAGEH1
MCRS1
MET
MTDH
NTRK1
NTRK2
PDLIM7
PLEKHA3
RAB6B
SH2B1
SHC1
SORBS1
SYK
TLE5
TLNRD1
USP2
ZNF414
ZNF417
62 interacting genes:
ABI2
AP5B1
BAG3
BSG
CATSPER1
CCDC185
DDX6
DGCR6
DNER
ENKD1
FAM214B
FAM71C
FAM90A1
FNDC11
FRS3
GEM
GFAP
GPATCH2L
HEY2
HNRNPD
HNRNPF
HSF2BP
HSPB7
IL16
IQGAP1
KANK2
MDM2
NUDT10
OTUD6A
PAK5
PARVG
PCBP1
PHF1
PIN1
PLEKHN1
PRKCA
PRKCB
PRKCZ
PRKD2
PSMF1
RASGEF1B
RET
RPP25
SCNM1
SH2B2
SH3BP2
SLAIN1
SMURF1
SPP1
TCF19
TNPO2
TP53
TPM2
TRAF2
TRAF3
TSG101
TSGA10IP
UBE2I
UBQLN4
WWP2
ZMYND11
ZNF165
Entrez ID
10603
9260
HPRD ID
16097
10436
Ensembl ID
ENSG00000160999
ENSG00000196923
Uniprot IDs
O14492
Q9NR12
PDB IDs
1Q2H
2Q3G
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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