EIF3G and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 29053956)
17

Data Source:
BioGRID (two hybrid)

		EIF3G	TRIM14
Description		eukaryotic translation initiation factor 3 subunit G	tripartite motif containing 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm	Mitochondrial Outer Membrane
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	Molecular_function Zinc Ion Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation	Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Interferon gamma signaling
Drugs
Diseases
GWAS			Multiple sclerosis ( 31604244)
Interacting Genes		26 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA METTL3 MPHOSPH6 MPP6 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14	52 interacting genes: ABCF3 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H CENPC CSPP1 EIF3G ETFBKMT FAT1 HERC3 ITM2A IVNS1ABP KAT2B KIF3A LAMTOR1 MITD1 MNAT1 MRPL24 NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR2G PPP2R3C RAB5A RAB9A RBM33 RLF RNF125 RNF20 SMARCB1 SMIM3 STK38 TAX1BP1 TMEM167A UBE2B UBE2N UNK WDR35 WRNIP1 ZC4H2 ZFP36L2 ZNF652
Entrez ID		8666	9830
HPRD ID		04886	05948
Ensembl ID		ENSG00000130811	ENSG00000106785
Uniprot IDs		O75821	A0A024R165 Q14142
PDB IDs		2CQ0 2MJC 5K0Y
Enriched GO Terms of Interacting Partners?
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