EIF3G and EIF3C

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		EIF3G	EIF3C
Description		eukaryotic translation initiation factor 3 subunit G	eukaryotic translation initiation factor 3 subunit C
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Interacting Genes		26 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA METTL3 MPHOSPH6 MPP6 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14	17 interacting genes: AAGAB ALKBH4 BCKDK CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 TACC3
Entrez ID		8666	8663
HPRD ID		04886	04889
Ensembl ID		ENSG00000130811	ENSG00000184110
Uniprot IDs		O75821	A0A024QYU9 Q99613
PDB IDs		2CQ0 2MJC 5K0Y	3J8B 3J8C
Enriched GO Terms of Interacting Partners?
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