EIF3G and EIF3H

Number of citations of the paper that reports this interaction (PubMedID 19615732)
634

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (in vivo, in vitro)

		EIF3G	EIF3H
Description		eukaryotic translation initiation factor 3 subunit G	eukaryotic translation initiation factor 3 subunit H
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Polysomal Ribosome Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Metallopeptidase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Proteolysis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 26965516 25990418 18372905 30529582 21761138 26151821 29471430 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		26 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA METTL3 MPHOSPH6 MPP6 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14	9 interacting genes: ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K NCK2 SORBS3 SPTBN1
Entrez ID		8666	8667
HPRD ID		04886	04885
Ensembl ID		ENSG00000130811	ENSG00000147677
Uniprot IDs		O75821	O15372 Q6IB98
PDB IDs		2CQ0 2MJC 5K0Y	3J8B 3J8C
Enriched GO Terms of Interacting Partners?
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