TRIM14 and PIM2

Number of citations of the paper that reports this interaction (PubMedID 29053956)
17

Data Source:
BioGRID (two hybrid)

		TRIM14	PIM2
Description		tripartite motif containing 14	Pim-2 proto-oncogene, serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane	Cytoplasm
	Molecular Function	Molecular_function Zinc Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Negative Regulation Of Protein Binding Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 31604244)
Interacting Genes		52 interacting genes: ABCF3 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H CENPC CSPP1 EIF3G ETFBKMT FAT1 HERC3 ITM2A IVNS1ABP KAT2B KIF3A LAMTOR1 MITD1 MNAT1 MRPL24 NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR2G PPP2R3C RAB5A RAB9A RBM33 RLF RNF125 RNF20 SMARCB1 SMIM3 STK38 TAX1BP1 TMEM167A UBE2B UBE2N UNK WDR35 WRNIP1 ZC4H2 ZFP36L2 ZNF652	14 interacting genes: ATXN1 BAD CUTC DAPK1 FBH1 FBXO7 GSK3B HNRNPH3 IKBKG NDUFB8 RPL21 SOCS1 TRIM14 ZNF821
Entrez ID		9830	11040
HPRD ID		05948	02244
Ensembl ID		ENSG00000106785	ENSG00000102096
Uniprot IDs		A0A024R165 Q14142	A0A024QYW7 Q9P1W9
PDB IDs			2IWI 4X7Q
Enriched GO Terms of Interacting Partners?
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