TBC1D22B and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TBC1D22B	SORBS3
Description		TBC1 domain family member 22B	sorbin and SH3 domain containing 3
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GO Annotations	Cellular Component		Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	GTPase Activator Activity Protein Binding Rab GTPase Binding 14-3-3 Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Platelet count ( 27863252)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		23 interacting genes: CALCOCO2 CCDC57 CDR2 DAPK1 DEUP1 FXR2 GOLGA2 HSD17B14 IKZF3 KRT40 LRRK2 MFHAS1 PNMA5 RBM10 SIAH1 SORBS3 TACC3 TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 VPS52	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		55633	10174
HPRD ID		15475	11535
Ensembl ID		ENSG00000065491	ENSG00000120896
Uniprot IDs		Q9NU19	O60504
PDB IDs		6D0S	2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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