SORBS3 and CPSF7

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SORBS3	CPSF7
Description		sorbin and SH3 domain containing 3	cleavage and polyadenylation specific factor 7
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Nucleus Nucleoplasm Cytoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex MRNA Cleavage Factor Complex Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing Protein Tetramerization Protein Heterotetramerization Pre-mRNA Cleavage Required For Polyadenylation MRNA Alternative Polyadenylation Messenger Ribonucleoprotein Complex Assembly
Pathways		Smooth Muscle Contraction	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	25 interacting genes: APBB1 ARMC7 ATXN1 CCDC86 CLK2 CSNK2A1 DVL2 EPM2AIP1 EWSR1 GCC1 ITCH NCK2 NUDT21 PRMT2 RBM10 RUNX1T1 SEC23B SMAD3 SNRNP25 SORBS3 SRPK2 TLE5 U2AF2 WBP4 WWOX
Entrez ID		10174	79869
HPRD ID		11535	16906
Ensembl ID		ENSG00000120896	ENSG00000149532
Uniprot IDs		O60504	B4DGF8 Q8N684
PDB IDs		2CT3 2DLM 2NWM 2YUP	3N9U
Enriched GO Terms of Interacting Partners?
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