SORBS3 and TBC1D22B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SORBS3	TBC1D22B
Description		sorbin and SH3 domain containing 3	TBC1 domain family member 22B
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	GTPase Activator Activity Protein Binding Rab GTPase Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Acne (severe) ( 24927181) Platelet count ( 27863252)
Interacting Genes		46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	23 interacting genes: CALCOCO2 CCDC57 CDR2 DAPK1 DEUP1 FXR2 GOLGA2 HSD17B14 IKZF3 KRT40 LRRK2 MFHAS1 PNMA5 RBM10 SIAH1 SORBS3 TACC3 TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 VPS52
Entrez ID		10174	55633
HPRD ID		11535	15475
Ensembl ID		ENSG00000120896	ENSG00000065491
Uniprot IDs		O60504	Q9NU19
PDB IDs		2CT3 2DLM 2NWM 2YUP	6D0S
Enriched GO Terms of Interacting Partners?
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