SORBS3 and ADAM15

Number of citations of the paper that reports this interaction (PubMedID 16374509)
37

Data Source:
HPRD (in vitro)

		SORBS3	ADAM15
Description		sorbin and SH3 domain containing 3	ADAM metallopeptidase domain 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Acrosomal Vesicle Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Motile Cilium Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia
Pathways		Smooth Muscle Contraction	Degradation of the extracellular matrix Invadopodia formation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chin dimples ( 27182965) General risk tolerance (MTAG) ( 30643258) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Systemic lupus erythematosus ( 28714469)
Interacting Genes		46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	32 interacting genes: ABL1 ARHGEF6 ARHGEF7 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		10174	8751
HPRD ID		11535	05674
Ensembl ID		ENSG00000120896	ENSG00000143537
Uniprot IDs		O60504	Q13444
PDB IDs		2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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