SORBS3 and PAK5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SORBS3	PAK5
Description		sorbin and SH3 domain containing 3	p21 (RAC1) activated kinase 5
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GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion	Nucleoplasm Cytoplasm Mitochondrion Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Cell Proliferation Cell Migration Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Smooth Muscle Contraction	Activation of RAC1
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)	Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2	21 interacting genes: ARMC7 ATPAF2 BAD CARD9 CCNG1 CDC42 CRBN EMD EXOSC1 FHL3 GCC1 INKA1 LENG1 LZTS2 PDLIM7 PRPF31 PSMF1 RAC1 SORBS3 TUBGCP4 UXT
Entrez ID		10174	57144
HPRD ID		11535	06423
Ensembl ID		ENSG00000120896	ENSG00000101349
Uniprot IDs		O60504	B0AZM9 Q9P286
PDB IDs		2CT3 2DLM 2NWM 2YUP	2F57
Enriched GO Terms of Interacting Partners?
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