ZBTB7B and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZBTB7B	SORBS3
Description		zinc finger and BTB domain containing 7B	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Transcription By RNA Polymerase II Ectoderm Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Regulation Of Transcription Involved In Cell Fate Commitment Interleukin-17 Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		19 interacting genes: BCL6 CRBN EP300 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 ZBTB5 ZNF277	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		51043	10174
HPRD ID		09625	11535
Ensembl ID		ENSG00000160685	ENSG00000120896
Uniprot IDs		O15156	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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