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CDC25B and MAPK9
Data Source:
BioGRID
(enzymatic study)
CDC25B
MAPK9
Description
cell division cycle 25B
mitogen-activated protein kinase 9
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Oocyte Maturation
Protein Phosphorylation
Female Meiosis I
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cytokinesis
Peptidyl-tyrosine Dephosphorylation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Mitotic Cell Cycle
Cell Division
Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Protein Phosphorylation
JNK Cascade
JUN Phosphorylation
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Peptidyl-serine Phosphorylation
Positive Regulation Of Protein Ubiquitination
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Rhythmic Process
Regulation Of DNA-binding Transcription Factor Activity
Protein Localization To Tricellular Tight Junction
Cellular Response To Cadmium Ion
Positive Regulation Of Podosome Assembly
Positive Regulation Of Transcription Factor Catabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Drugs
L-cysteic acid
Minocycline
N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
Fostamatinib
Halicin
Diseases
GWAS
Basophil percentage of granulocytes (
27863252
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Blood protein levels (
30072576
)
Interacting Genes
28 interacting genes:
AATK
AR
AURKA
BRSK1
BRSK2
CDC14A
CDK1
CDK2
CDK5
CHEK1
CREBBP
CSNK2A1
CSNK2B
ESR1
FHL3
KAT2B
MAPK14
MAPK9
MAPKAPK2
MELK
PGR
PSME3
SFN
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
112 interacting genes:
ACP5
AKT1
ARRB1
ARRB2
ATF2
ATF7
BCL2L1
BCL2L11
BNIP5
C1orf105
C1orf94
CASP3
CBLL2
CCDC33
CDC16
CDC25B
CDC25C
CEP126
CEP44
CLU
CTBP1
CTNNB1
CYHR1
DCX
DTX3
DUSP10
DUSP16
DUSP19
DUSP4
EEF2K
EFHC2
EGFR
ELK1
ELK3
ENKD1
FBXO7
GFAP
GOLGA6A
GRB2
GSC2
H3-3A
HDAC9
HSF1
IHO1
IRS1
ITGB3BP
JDP2
JUN
JUNB
JUND
KLHL8
KPNA3
L3MBTL3
LHX3
LMAN2
LNX1
LNX2
LZTS1
MACF1
MAP2K4
MAP2K7
MAP3K1
MAP3K10
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAPK5
MAPKBP1
MAPT
MCRS1
MED12L
MEOX1
MLIP
NCF1
NCSTN
NFATC3
NFATC4
NHSL2
PAX5
PBX4
PICK1
POU6F2
PPARG
PRKD1
PSEN1
RASL10B
RB1
RPS6KB1
RSPO4
SAXO1
SDCBP
SF3B4
SH3BP5
SHMT1
SMAD2
SMAD3
SMCO3
SSU72
TCP10L
TEX11
TOB1
TP53
TRAF2
TUSC2
WDR62
XPNPEP1
XPO7
ZBTB25
ZC2HC1C
ZNF138
ZNF559
ZNHIT1
Entrez ID
994
5601
HPRD ID
00307
04206
Ensembl ID
ENSG00000101224
ENSG00000050748
Uniprot IDs
B3KS38
B4DIG0
B4DQZ3
B4DRC3
E1YMX4
G8JLH2
P30305
Q6MZW8
D7R525
D7R526
P45984
PDB IDs
1CWR
1CWS
1CWT
1QB0
1YM9
1YMD
1YMK
1YML
1YS0
2A2K
2IFD
2IFV
2UZQ
3FQT
3FQU
4WH7
4WH9
3E7O
3NPC
7CML
Enriched GO Terms of Interacting Partners
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