CDC25B and BRSK2

Data Source:
HPRD (in vitro)

		CDC25B	BRSK2
Description		cell division cycle 25B	BR serine/threonine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol	Nucleus Cytoplasm Endoplasmic Reticulum Centrosome Perinuclear Region Of Cytoplasm Distal Axon
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Tau Protein Binding Tau-protein Kinase Activity ATPase Binding ATPase Regulator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Axonogenesis Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Actin Cytoskeleton Reorganization Intracellular Signal Transduction ERAD Pathway Cellular Response To Glucose Starvation Regulation Of ATPase Activity Regulation Of Axonogenesis Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Synaptic Vesicle Clustering
Pathways		Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		L-cysteic acid
Diseases
GWAS		Basophil percentage of granulocytes ( 27863252) Cognitive decline rate in late mild cognitive impairment ( 26252872) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Brain morphology (MOSTest) ( 32665545) Gout ( 32238385) Heroin dependence ( 27936112) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ	7 interacting genes: CDC25B CDC25C COPS5 MAPT TRAF6 VCP WEE1
Entrez ID		994	9024
HPRD ID		00307	11611
Ensembl ID		ENSG00000101224	ENSG00000174672
Uniprot IDs		B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305 Q6MZW8	A0A024RCE9 A0A140VJF6 B4DLY3 Q8IWQ3
PDB IDs		1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
Enriched GO Terms of Interacting Partners?
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