MAPK9 and ATF2

Data Source:
HPRD (in vitro)

		MAPK9	ATF2
Description		mitogen-activated protein kinase 9	activating transcription factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break H4 Histone Acetyltransferase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding H4 Histone Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding H2B Histone Acetyltransferase Activity Protein-containing Complex Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation JNK Cascade JUN Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Response To Water Deprivation Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Neuron Apoptotic Process Histone H4 Acetylation Histone H2B Acetylation Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Adipose Tissue Development Amelogenesis Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Circadian Clock Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs		Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin	Pseudoephedrine
Diseases
GWAS		Blood protein levels ( 30072576)	Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		112 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BNIP5 C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RASL10B RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZNF138 ZNF559 ZNHIT1	63 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CENPQ CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FOS FOSB FOSL1 FOSL2 GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1
Entrez ID		5601	1386
HPRD ID		04206	00443
Ensembl ID		ENSG00000050748	ENSG00000115966
Uniprot IDs		D7R525 D7R526 P45984	A4D7V5 P15336
PDB IDs		3E7O 3NPC 7CML	1BHI 1T2K 4H36
Enriched GO Terms of Interacting Partners?
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