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EIF5 and HSPB1
Data Source:
BioGRID
(two hybrid)
EIF5
HSPB1
Description
eukaryotic translation initiation factor 5
heat shock protein family B (small) member 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Proteasome Complex
Extracellular Space
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Focal Adhesion
Extracellular Exosome
Axon Cytoplasm
Molecular Function
RNA Binding
Translation Initiation Factor Activity
GDP-dissociation Inhibitor Activity
Protein Binding
GTP Binding
Cadherin Binding
Eukaryotic Initiation Factor EIF2 Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Protein Folding Chaperone
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Formation Of Translation Preinitiation Complex
Formation Of Cytoplasmic Translation Initiation Complex
Regulation Of Translational Initiation
Activation Of GTPase Activity
Retina Homeostasis
Regulation Of Protein Phosphorylation
Regulation Of Translational Initiation
Negative Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Response To Virus
Regulation Of Autophagy
Viral Process
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Chaperone-mediated Protein Folding
Platelet Aggregation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Anterograde Axonal Protein Transport
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
VEGFA-VEGFR2 Pathway
AUF1 (hnRNP D0) binds and destabilizes mRNA
MAPK6/MAPK4 signaling
Extra-nuclear estrogen signaling
Drugs
Apatorsen
Artenimol
Phenethyl Isothiocyanate
Diseases
Distal hereditary motor neuropathies (dHMN)
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Body mass index (
26426971
)
Monocyte count (
29403010
)
Number of sexual partners (
30643258
)
Red blood cell traits (
23222517
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Schizophrenia (
30285260
)
Interacting Genes
16 interacting genes:
APP
CDC42
CSNK2A1
CSNK2B
DUSP12
EIF1AX
EIF1AY
EIF2S2
EIF3D
EIF3G
EIF4G1
EIF4G2
HSPB1
NCBP2
NRGN
PUM1
254 interacting genes:
ACAP2
ACBD6
ACTC1
ACTN1
ACTN2
ACTN4
ADCY9
ADD3
ADPRS
AGAP10P
AGAP3
AGAP4
AGAP5
AGAP7P
AKT1
ALPI
AMD1
ANAPC7
ANK1
ANKRD7
ANXA1
AP2B1
APPL1
ARHGAP28
ARHGEF7
ARIH1
ARMT1
ARRDC5
ATXN10
BAG3
BICDL1
BVES
C11orf98
C2orf73
CAMK1
CBX1
CCDC32
CCDC70
CCHCR1
CCNC
CCNDBP1
CCNO
CDC123
CDK5RAP3
CENPK
CEP78
CETN3
CFAP251
CLCN3
CPSF3
CRNKL1
CRYAA
CRYAB
CRYBB2
CRYGC
CS
CYCS
DAXX
DES
DMAP1
DNAJC21
ECPAS
EHD1
EIF1AX
EIF2S1
EIF3M
EIF4G1
EIF4G3
EIF5
ENPP2
EPB41L1
EPB41L2
EPB41L3
ERCC5
ERICH6
ESR1
FAM71D
FLNB
FXR1
GAPVD1
GDI2
GLMN
GNPAT
GOLGA8A
GRIPAP1
GRK3
GSTO1
GTSF1
GUCA1A
HAUS8
HDLBP
HECTD1
HNRNPA2B1
HNRNPD
HNRNPF
HNRNPU
HSP90AB1
HSPA4
HSPA5
HSPB8
HUWE1
IARS2
IGBP1
IGSF21
INPP5K
INS
ISG20L2
KANSL1
KCMF1
KCTD3
KLC1
KNSTRN
KPNA3
KRT18
KRT72
LBP
LIG1
LONRF1
LRIF1
LSM3
LUZP1
MAPK14
MAPKAPK2
MAPKAPK3
MAPKAPK5
MAPT
MCM6
MDH2
MED31
MFAP1
MPHOSPH6
MRGBP
MRPL28
MRPL40
MRPS23
MSL1
MTIF2
MYG1
MYL12A
MYL12B
MYL9
MYLK
NAP1L1
NAPA
NBAS
NCKIPSD
NEK10
NEXN
NFKBIA
NFU1
NSMCE4A
NVL
OBSL1
OPTN
OSBPL9
PAF1
PALM3
PELO
PGM2
PHYHIPL
PLG
PNISR
PNPT1
POP7
PPA1
PPM1A
PPP2R3C
PRPF19
PRPF40A
PSMA3
PSMA6
PSMB2
PSMC1
PSMD1
PTGES3
PTPN3
PTPRA
RAB41
RAD23A
RALA
RASSF9
RBM25
RBM39
RBM48
RBPJ
RPAP3
RPSA
RSPH3
RYBP
S100A4
SAT1
SBF1
SEC13
SERTAD1
SF3A3
SF3B3
SLC7A9
SMARCA2
SMARCA4
SMARCD1
SNRNP200
SNRPF
SPACA7
SPATA7
SPIN1
SPTBN1
SQSTM1
SRP72
STUB1
SUMO2
SUPT5H
SYCE1
TARBP2
TARS1
TBC1D1
TBC1D3B
TGFB1I1
TGM1
THOC5
TJP2
TMCO3
TOMM70
TOX4
TP53
TPT1
TRIM24
TRIM54
TRIM55
TRIM63
TSNAXIP1
TTC3
TTC39C
TXNL1
UCHL5
UFD1
UQCC2
UQCRB
VIM
WASHC3
WDR83
WWP1
XPO1
XRCC5
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB17
ZBTB37
ZFAT
ZNF131
ZNF197
ZNRF3
Entrez ID
1983
3315
HPRD ID
03417
09076
Ensembl ID
ENSG00000100664
ENSG00000106211
Uniprot IDs
A0A024R6Q1
P55010
P04792
V9HW43
PDB IDs
2E9H
2G2K
2IU1
2N3J
3Q9P
3Q9Q
4MJH
6DV5
6GJH
Enriched GO Terms of Interacting Partners
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