EIF5 and EIF3D

Data Source:
HPRD (in vitro)

		EIF5	EIF3D
Description		eukaryotic translation initiation factor 5	eukaryotic translation initiation factor 3 subunit D
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	RNA Binding Translation Initiation Factor Activity GDP-dissociation Inhibitor Activity Protein Binding GTP Binding Cadherin Binding Eukaryotic Initiation Factor EIF2 Binding	RNA Binding Translation Initiation Factor Activity Protein Binding MRNA Cap Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Translational Initiation Activation Of GTPase Activity	Formation Of Cytoplasmic Translation Initiation Complex Cap-dependent Translational Initiation Translational Initiation Positive Regulation Of Translation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation Positive Regulation Of MRNA Binding
Pathways		Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Monocyte count ( 29403010) Number of sexual partners ( 30643258) Red blood cell traits ( 23222517)
Interacting Genes		16 interacting genes: APP CDC42 CSNK2A1 CSNK2B DUSP12 EIF1AX EIF1AY EIF2S2 EIF3D EIF3G EIF4G1 EIF4G2 HSPB1 NCBP2 NRGN PUM1	31 interacting genes: ANKRD28 BEND5 CCDC125 CCDC57 CDC42 CEP70 CREBBP DNAJB11 DVL3 EIF3G EIF3J EIF3L EIF5 ERCC6 GOLGA6L9 HOMER3 HOOK2 HSF2BP KIFC3 LZTS2 MORN3 MTUS2 PHLDA1 PICK1 POLR2G REL SAT1 TFIP11 TRIM23 TRIM27 ZRANB1
Entrez ID		1983	8664
HPRD ID		03417	04888
Ensembl ID		ENSG00000100664	ENSG00000100353
Uniprot IDs		A0A024R6Q1 P55010	O15371
PDB IDs		2E9H 2G2K 2IU1	6YBD 6YBS 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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