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RAPGEF2 and RAP2B
Data Source:
HPRD
(in vitro, in vivo)
RAPGEF2
RAP2B
Description
Rap guanine nucleotide exchange factor 2
RAP2B, member of RAS oncogene family
Image
GO Annotations
Cellular Component
Cytoplasm
Late Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Membrane
Apical Plasma Membrane
Endocytic Vesicle
Protein-containing Complex
Neuron Projection
Neuronal Cell Body
Synapse
Perinuclear Region Of Cytoplasm
Cytosol
Plasma Membrane
Bicellular Tight Junction
Membrane
Specific Granule Membrane
Cell-cell Contact Zone
Membrane Raft
Recycling Endosome Membrane
Extracellular Exosome
Tertiary Granule Membrane
Molecular Function
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Diacylglycerol Binding
PDZ Domain Binding
CAMP Binding
CGMP Binding
Beta-1 Adrenergic Receptor Binding
WW Domain Binding
Phosphatidic Acid Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Domain Specific Binding
Biological Process
MAPK Cascade
Blood Vessel Development
Neuron Migration
G Protein-coupled Receptor Signaling Pathway
Neuropeptide Signaling Pathway
Small GTPase Mediated Signal Transduction
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Neuron Projection Development
CAMP-mediated Signaling
Ventricular System Development
Forebrain Neuron Development
Microvillus Assembly
Neuron Projection Development
Brain-derived Neurotrophic Factor Receptor Signaling Pathway
Positive Regulation Of Protein Binding
Rap Protein Signal Transduction
Intracellular Signal Transduction
Nerve Growth Factor Signaling Pathway
Positive Regulation Of GTPase Activity
Positive Regulation Of CAMP-mediated Signaling
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Melanin Biosynthetic Process
Regulation Of Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Cellular Response To CGMP
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Protein Localization To Plasma Membrane
Establishment Of Endothelial Intestinal Barrier
Regulation Of Cell Junction Assembly
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of Dendritic Cell Apoptotic Process
Positive Regulation Of Vasculogenesis
Positive Regulation Of Neuron Migration
Signal Transduction
Microvillus Assembly
Platelet Activation
Negative Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Rap Protein Signal Transduction
Neutrophil Degranulation
Regulation Of Protein Tyrosine Kinase Activity
Platelet Aggregation
Establishment Of Endothelial Intestinal Barrier
Pathways
RAF/MAP kinase cascade
Neutrophil degranulation
Drugs
Diseases
GWAS
Dietary fat liking (
32516399
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Molybdenum levels (
26025379
)
Uterine fibroid number (single vs multiple) (
30196971
)
Cerebral amyloid deposition (PET imaging) (
30361487
)
Chronotype (
30696823
)
Cutaneous melanoma or hair colour (
32341527
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Serum sulfate level (
27412988
)
Interacting Genes
13 interacting genes:
CTNNB1
HSPA1A
IL16
KIF5A
KIF5B
MAGI2
MOB4
MT-ATP8
NEDD4
RALGDS
RAP1A
RAP2B
SPP1
9 interacting genes:
CAMK2B
PDE6D
RALGDS
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF5
RASSF5
RUNDC3A
Entrez ID
9693
5912
HPRD ID
19358
01548
Ensembl ID
ENSG00000109756
ENSG00000181467
Uniprot IDs
Q9Y4G8
P61225
PDB IDs
6QDT
1N4P
1N4Q
1N4R
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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