RAPGEF2 and KIF5B

Data Source:
BioGRID (two hybrid)

		RAPGEF2	KIF5B
Description		Rap guanine nucleotide exchange factor 2	kinesin family member 5B
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GO Annotations	Cellular Component	Cytoplasm Late Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Apical Plasma Membrane Endocytic Vesicle Protein-containing Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm	Cytosol Kinesin Complex Microtubule Membrane Vesicle Dendrite Cytoplasm Centriolar Satellite Ciliary Rootlet Axonal Growth Cone Phagocytic Vesicle Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Diacylglycerol Binding PDZ Domain Binding CAMP Binding CGMP Binding Beta-1 Adrenergic Receptor Binding WW Domain Binding Phosphatidic Acid Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding JUN Kinase Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Identical Protein Binding Cadherin Binding Microtubule Lateral Binding
	Biological Process	MAPK Cascade Blood Vessel Development Neuron Migration G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Ventricular System Development Forebrain Neuron Development Microvillus Assembly Neuron Projection Development Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Rap Protein Signal Transduction Intracellular Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Negative Regulation Of Dendrite Morphogenesis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To CGMP Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Vasculogenesis Positive Regulation Of Neuron Migration	Microtubule-based Movement Cytoplasm Organization Axon Guidance Hippocampus Development Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Vesicle Fusion Positive Regulation Of Synaptic Transmission, GABAergic Stress Granule Disassembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Membrane Potential Positive Regulation Of Potassium Ion Transport Vesicle Transport Along Microtubule Synaptic Vesicle Transport Centrosome Localization Cellular Response To Interferon-gamma Plus-end-directed Vesicle Transport Along Microtubule Positive Regulation Of Intracellular Protein Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Voltage-gated Sodium Channel Activity Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		RAF/MAP kinase cascade	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Dietary fat liking ( 32516399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Molybdenum levels ( 26025379) Uterine fibroid number (single vs multiple) ( 30196971)	Anti-saccade response ( 29064472) Bipolar disorder with mood-incongruent psychosis ( 23092984) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycine levels ( 30837465) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: CTNNB1 HSPA1A IL16 KIF5A KIF5B MAGI2 MOB4 MT-ATP8 NEDD4 RALGDS RAP1A RAP2B SPP1	36 interacting genes: APC BAG4 CCDC136 CDC5L CDR2 DTNB FHL2 GCC1 GSK3B HSF2BP KIF5A KLC3 KTN1 LBX1 MEOX2 MYO5A NCOA2 NDRG1 POLR2G POU6F2 PRKAR1B PRKAR2B RAPGEF2 RRBP1 SNAP23 SNAP25 SUMO2 SYBU TAX1BP1 VPS52 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZBTB8A
Entrez ID		9693	3799
HPRD ID		19358	07214
Ensembl ID		ENSG00000109756	ENSG00000170759
Uniprot IDs		Q9Y4G8	P33176 Q6P164 V9HW29
PDB IDs		6QDT	1BG2 1MKJ 2P4N 3J8X 3J8Y 4HNA 4LNU 5LT0 5LT1 5LT2 5LT3 5LT4 6OJQ
Enriched GO Terms of Interacting Partners?
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