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BAG3 and LRRK2
Data Source:
BioGRID
(pull down)
BAG3
LRRK2
Description
BAG cochaperone 3
leucine rich repeat kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Aggresome
Z Disc
Neuron Projection
Chaperone Complex
Golgi Membrane
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Plasma Membrane
Microvillus
Inclusion Body
Axon
Dendrite
Growth Cone
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Membrane Raft
Extracellular Exosome
Endoplasmic Reticulum Exit Site
Multivesicular Body, Internal Vesicle
Postsynapse
Glutamatergic Synapse
Caveola Neck
Presynaptic Cytosol
Ribonucleoprotein Complex
Wnt Signalosome
Molecular Function
Adenyl-nucleotide Exchange Factor Activity
Protein Binding
Heat Shock Protein Binding
Protein-containing Complex Binding
Cadherin Binding
Dynein Intermediate Chain Binding
Chaperone Binding
SNARE Binding
Magnesium Ion Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine Phosphatase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Microtubule Binding
Tubulin Binding
Kinase Activity
Syntaxin-1 Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Small GTPase Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Co-receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Beta-catenin Destruction Complex Binding
Biological Process
Autophagosome Assembly
Protein Folding
Brain Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Spinal Cord Development
Cellular Response To Heat
Cellular Response To Unfolded Protein
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Muscle Cell Cellular Homeostasis
Positive Regulation Of Protein Export From Nucleus
Regulation Of Catalytic Activity
Protein Stabilization
Chaperone-mediated Autophagy
Aggresome Assembly
Cellular Response To Mechanical Stimulus
Chaperone-mediated Protein Transport
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Protein Transport Along Microtubule
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Aggrephagy
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Protein Dephosphorylation
Protein Import Into Nucleus
Endocytosis
Autophagy
Response To Oxidative Stress
Mitochondrion Organization
Endoplasmic Reticulum Organization
Golgi Organization
Lysosome Organization
Signal Transduction
Spermatogenesis
Neuromuscular Junction Development
Determination Of Adult Lifespan
Cellular Response To Starvation
Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Regulation Of Neuron Maturation
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Striatum Development
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Lysosomal Lumen PH
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
GTP Metabolic Process
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Mitochondrion Localization
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Protein Localization To Endoplasmic Reticulum Exit Site
Neuron Death
Cellular Response To Manganese Ion
Cellular Response To Organic Cyclic Compound
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Excitatory Postsynaptic Potential
Neuron Projection Arborization
Positive Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Histone Deacetylase Activity
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Positive Regulation Of Microglial Cell Activation
Wnt Signalosome Assembly
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of CAMKK-AMPK Signaling Cascade
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Pathways
Regulation of HSF1-mediated heat shock response
PTK6 promotes HIF1A stabilization
Drugs
Fostamatinib
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Diastolic blood pressure (
27841878
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Heart failure (
31919418
)
Idiopathic dilated cardiomyopathy (
21459883
)
Left ventricular ejection fraction (
32382064
32605384
)
Left ventricular end-systolic volume (
32382064
)
Parkinson's disease (
32201043
27182965
28892059
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
21102463
)
Daytime sleep phenotypes (
27126917
)
Inflammatory bowel disease (
28067908
23128233
)
Leprosy (
25642632
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
32888494
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
25064009
31660654
27182965
24842889
28892059
22438815
28011712
21738487
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Interacting Genes
75 interacting genes:
ACD
ARRDC3
ATN1
ATXN7L2
BAIAP2L1
BCL2
CRYAB
CTDSP1
CYSRT1
CYSTM1
DAZAP2
DNM2
DTX3
DVL1
DVL2
DYNLT1
EGR4
EYA2
FAM168B
FAM189A2
FBXO7
FOXD4L1
GGN
GLIS3
HELT
HSPA1A
HSPA5
HSPA8
HSPB1
HSPB2
HSPB2-C11orf52
HSPB7
HSPB8
INCA1
LENG8
LITAF
LRRK1
LRRK2
MAGED1
MDFI
MRPL38
NIBAN3
NOTO
NR1H3
PDE9A
PDLIM7
PIH1D2
PLA2G10
PLCG1
PLEKHB1
POT1
PRDM6
PRKAR1B
PRR34
PTPN21
RUNX1
SF3B4
SHISA6
SIAH1
SPRY2
SRPK2
TBC1D3B
TBC1D3G
TINF2
TMEM174
TNK2
TP53BP2
TRIB3
TRIM27
TRIP6
TSC1
UNKL
VPS37B
WBP2
WNK1
144 interacting genes:
ABLIM1
ACTB
AFF4
AHCYL1
AHDC1
AKT1
ANKS4B
APEX2
APP
ARFGAP1
ARHGEF7
AURKB
BAG1
BAG2
BAG3
C18orf25
C1orf87
CAMK1D
CBLB
CCDC43
CDC42EP3
CDKL3
CETN3
CHGB
CRMP1
CUEDC1
CXCL11
CYREN
DBF4B
DDIT4
DIDO1
DUX3
DVL1
DVL2
DVL3
DYRK2
E2F4
ECHS1
EIF4EBP1
ENKUR
ESRRG
FAM184A
FAM47B
FAM90A1
FANCM
FCHSD1
GTSF1
HIF1A
HSPD1
ITGB3BP
JHY
KCTD18
KDM4D
KLC2
L3MBTL3
LARP4
LARP7
LATS1
LGALS8
LINC01139
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MATK
MBP
MLLT3
MRGBP
MRPL19
MRPL28
MTA1
MYL9
NCBP3
NDUFAF7
NEK1
NSL1
PADI4
PDCL
PHF20L1
PIK3CB
PIK3R1
PLK1
POLR2M
POU5F1
PPP1R8
PRKCZ
PSME3IP1
PTPN23
RAB11FIP2
RAD51AP1
RALYL
RAPGEF4
RASL11B
RBIS
RHBDD1
RIPK2
RIT1
RPAP3
RPS6KB2
SCEL
SERF1A
SH3GL2
SH3GL3
SKA3
SMTNL2
SPATS2
SQSTM1
STAC
STK24
STK25
STK3
STK40
STN1
STRBP
STUB1
SUPT4H1
SYNJ1
TAOK3
TAS2R60
TBC1D22B
TCEA2
TCP10L
TGIF2LX
TRAF2
TTC27
TTLL1
TUBA1A
UBXN10
UFD1
UQCRB
USP39
VASH2
VGLL4
VN1R1
WSB1
WT1-AS
XIRP2
ZAP70
ZFAND5
ZMYM5
ZRANB2
Entrez ID
9531
120892
HPRD ID
04860
10613
Ensembl ID
ENSG00000151929
ENSG00000188906
Uniprot IDs
O95817
Q17RV3
Q5S007
PDB IDs
2ZEJ
3D6T
5MY9
5MYC
6DLO
6DLP
6OJE
6OJF
6VNO
6VP6
6VP7
6XR4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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