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LRRK2 and STUB1
Data Source:
BioGRID
(pull down)
LRRK2
STUB1
Description
leucine rich repeat kinase 2
STIP1 homology and U-box containing protein 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Plasma Membrane
Microvillus
Inclusion Body
Axon
Dendrite
Growth Cone
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Membrane Raft
Extracellular Exosome
Endoplasmic Reticulum Exit Site
Multivesicular Body, Internal Vesicle
Postsynapse
Glutamatergic Synapse
Caveola Neck
Presynaptic Cytosol
Ribonucleoprotein Complex
Wnt Signalosome
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Z Disc
Ubiquitin Conjugating Enzyme Complex
Nuclear Inclusion Body
Chaperone Complex
Molecular Function
SNARE Binding
Magnesium Ion Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine Phosphatase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Microtubule Binding
Tubulin Binding
Kinase Activity
Syntaxin-1 Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Small GTPase Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Co-receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Beta-catenin Destruction Complex Binding
G Protein-coupled Receptor Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Kinase Binding
Hsp70 Protein Binding
Protein-macromolecule Adaptor Activity
TPR Domain Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein Homodimerization Activity
SMAD Binding
Tau Protein Binding
Chaperone Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Protein Dephosphorylation
Protein Import Into Nucleus
Endocytosis
Autophagy
Response To Oxidative Stress
Mitochondrion Organization
Endoplasmic Reticulum Organization
Golgi Organization
Lysosome Organization
Signal Transduction
Spermatogenesis
Neuromuscular Junction Development
Determination Of Adult Lifespan
Cellular Response To Starvation
Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Regulation Of Neuron Maturation
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Striatum Development
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Lysosomal Lumen PH
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
GTP Metabolic Process
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Mitochondrion Localization
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Protein Localization To Endoplasmic Reticulum Exit Site
Neuron Death
Cellular Response To Manganese Ion
Cellular Response To Organic Cyclic Compound
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Excitatory Postsynaptic Potential
Neuron Projection Arborization
Positive Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Histone Deacetylase Activity
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Positive Regulation Of Microglial Cell Activation
Wnt Signalosome Assembly
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of CAMKK-AMPK Signaling Cascade
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Protein Polyubiquitination
Response To Ischemia
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Glucocorticoid Metabolic Process
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Heat
ERBB2 Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Ubiquitin-protein Transferase Activity
Protein Maturation
Protein Autoubiquitination
Chaperone-mediated Autophagy
Protein K63-linked Ubiquitination
Cellular Response To Misfolded Protein
Cellular Response To Hypoxia
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways
PTK6 promotes HIF1A stabilization
Downregulation of TGF-beta receptor signaling
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
Regulation of RUNX2 expression and activity
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
21102463
)
Daytime sleep phenotypes (
27126917
)
Inflammatory bowel disease (
28067908
23128233
)
Leprosy (
25642632
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
32888494
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
25064009
31660654
27182965
24842889
28892059
22438815
28011712
21738487
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Interacting Genes
144 interacting genes:
ABLIM1
ACTB
AFF4
AHCYL1
AHDC1
AKT1
ANKS4B
APEX2
APP
ARFGAP1
ARHGEF7
AURKB
BAG1
BAG2
BAG3
C18orf25
C1orf87
CAMK1D
CBLB
CCDC43
CDC42EP3
CDKL3
CETN3
CHGB
CRMP1
CUEDC1
CXCL11
CYREN
DBF4B
DDIT4
DIDO1
DUX3
DVL1
DVL2
DVL3
DYRK2
E2F4
ECHS1
EIF4EBP1
ENKUR
ESRRG
FAM184A
FAM47B
FAM90A1
FANCM
FCHSD1
GTSF1
HIF1A
HSPD1
ITGB3BP
JHY
KCTD18
KDM4D
KLC2
L3MBTL3
LARP4
LARP7
LATS1
LGALS8
LINC01139
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MATK
MBP
MLLT3
MRGBP
MRPL19
MRPL28
MTA1
MYL9
NCBP3
NDUFAF7
NEK1
NSL1
PADI4
PDCL
PHF20L1
PIK3CB
PIK3R1
PLK1
POLR2M
POU5F1
PPP1R8
PRKCZ
PSME3IP1
PTPN23
RAB11FIP2
RAD51AP1
RALYL
RAPGEF4
RASL11B
RBIS
RHBDD1
RIPK2
RIT1
RPAP3
RPS6KB2
SCEL
SERF1A
SH3GL2
SH3GL3
SKA3
SMTNL2
SPATS2
SQSTM1
STAC
STK24
STK25
STK3
STK40
STN1
STRBP
STUB1
SUPT4H1
SYNJ1
TAOK3
TAS2R60
TBC1D22B
TCEA2
TCP10L
TGIF2LX
TRAF2
TTC27
TTLL1
TUBA1A
UBXN10
UFD1
UQCRB
USP39
VASH2
VGLL4
VN1R1
WSB1
WT1-AS
XIRP2
ZAP70
ZFAND5
ZMYM5
ZRANB2
126 interacting genes:
ABL1
ACD
AHR
AQP2
AR
ATCAY
ATXN3
BACE1
BAG1
BAG5
BCR
BMPR1B
CASP6
CCL28
CDK4
CDKN1A
CFTR
CIP2A
CTBP2
CTNNB1
CYP2E1
CYP3A4
DAPK1
DAXX
DNAAF4
DNAJB1
E2F8
EIF5A
ERBB2
ERG
ERN1
ESR1
FADD
FBXO2
FBXO27
FOXP3
GHR
GPR37
GUCY1A1
GUCY1A2
HIF1A
HSF1
HSP90AA1
HSPA1A
HSPA1B
HSPA4
HSPA8
HSPA9
HSPB1
INSR
JOSD1
JOSD2
KHDRBS1
LRRK1
LRRK2
MAP3K11
MAP3K2
MAP3K21
MAPK3
MAPT
MCF2
MFHAS1
MITF
MPP1
MST1R
MYOCD
NOS1
NQO1
NR3C1
OLFM3
PA2G4
PFN1
PLK1
POLB
POT1
POU5F1
PPARG
PPP3CA
PRKACA
PRKCZ
PRKN
PRMT1
PRMT5
PSMA3
PSMD4
PTEN
RAF1
RGS17
RHBDF2
RUNX2
RUSC1
S100A2
S100P
SIRT6
SMAD1
SMAD2
SMAD3
SMAD4
SMG5
SMURF1
SNPH
SRC
TAL1
TERF1
TGFBR1
TINF2
TPD52
TRAF6
TXN2
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L3
UBE2N
UBE2Q1
UBE2V1
UBE2V2
UBE2W
VCP
XIAP
Entrez ID
120892
10273
HPRD ID
10613
06232
Ensembl ID
ENSG00000188906
ENSG00000103266
Uniprot IDs
Q17RV3
Q5S007
Q9UNE7
PDB IDs
2ZEJ
3D6T
5MY9
5MYC
6DLO
6DLP
6OJE
6OJF
6VNO
6VP6
6VP7
6XR4
4KBQ
6EFK
6NSV
Enriched GO Terms of Interacting Partners
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