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LRRK2 and TUBA1A
Data Source:
BioGRID
(enzymatic study)
LRRK2
TUBA1A
Description
leucine rich repeat kinase 2
tubulin alpha 1a
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Plasma Membrane
Microvillus
Inclusion Body
Axon
Dendrite
Growth Cone
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Membrane Raft
Extracellular Exosome
Endoplasmic Reticulum Exit Site
Multivesicular Body, Internal Vesicle
Postsynapse
Glutamatergic Synapse
Caveola Neck
Presynaptic Cytosol
Ribonucleoprotein Complex
Wnt Signalosome
Nucleus
Cytoplasm
Cytosol
Microtubule
Cytoplasmic Microtubule
Microtubule Cytoskeleton
Neuromuscular Junction
Cytoplasmic Ribonucleoprotein Granule
Myelin Sheath
Membrane Raft
Recycling Endosome
Extracellular Exosome
Molecular Function
SNARE Binding
Magnesium Ion Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine Phosphatase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Microtubule Binding
Tubulin Binding
Kinase Activity
Syntaxin-1 Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Small GTPase Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Co-receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Beta-catenin Destruction Complex Binding
GTPase Activity
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Protein Domain Specific Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Protein Dephosphorylation
Protein Import Into Nucleus
Endocytosis
Autophagy
Response To Oxidative Stress
Mitochondrion Organization
Endoplasmic Reticulum Organization
Golgi Organization
Lysosome Organization
Signal Transduction
Spermatogenesis
Neuromuscular Junction Development
Determination Of Adult Lifespan
Cellular Response To Starvation
Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Regulation Of Neuron Maturation
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Striatum Development
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Lysosomal Lumen PH
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
GTP Metabolic Process
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Mitochondrion Localization
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Protein Localization To Endoplasmic Reticulum Exit Site
Neuron Death
Cellular Response To Manganese Ion
Cellular Response To Organic Cyclic Compound
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Excitatory Postsynaptic Potential
Neuron Projection Arborization
Positive Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Histone Deacetylase Activity
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Positive Regulation Of Microglial Cell Activation
Wnt Signalosome Assembly
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of CAMKK-AMPK Signaling Cascade
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cytoskeleton-dependent Intracellular Transport
Regulation Of Synapse Organization
Cell Division
Ciliary Basal Body-plasma Membrane Docking
Pathways
PTK6 promotes HIF1A stabilization
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
Drugs
Fostamatinib
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
21102463
)
Daytime sleep phenotypes (
27126917
)
Inflammatory bowel disease (
28067908
23128233
)
Leprosy (
25642632
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
32888494
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
25064009
31660654
27182965
24842889
28892059
22438815
28011712
21738487
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
144 interacting genes:
ABLIM1
ACTB
AFF4
AHCYL1
AHDC1
AKT1
ANKS4B
APEX2
APP
ARFGAP1
ARHGEF7
AURKB
BAG1
BAG2
BAG3
C18orf25
C1orf87
CAMK1D
CBLB
CCDC43
CDC42EP3
CDKL3
CETN3
CHGB
CRMP1
CUEDC1
CXCL11
CYREN
DBF4B
DDIT4
DIDO1
DUX3
DVL1
DVL2
DVL3
DYRK2
E2F4
ECHS1
EIF4EBP1
ENKUR
ESRRG
FAM184A
FAM47B
FAM90A1
FANCM
FCHSD1
GTSF1
HIF1A
HSPD1
ITGB3BP
JHY
KCTD18
KDM4D
KLC2
L3MBTL3
LARP4
LARP7
LATS1
LGALS8
LINC01139
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MATK
MBP
MLLT3
MRGBP
MRPL19
MRPL28
MTA1
MYL9
NCBP3
NDUFAF7
NEK1
NSL1
PADI4
PDCL
PHF20L1
PIK3CB
PIK3R1
PLK1
POLR2M
POU5F1
PPP1R8
PRKCZ
PSME3IP1
PTPN23
RAB11FIP2
RAD51AP1
RALYL
RAPGEF4
RASL11B
RBIS
RHBDD1
RIPK2
RIT1
RPAP3
RPS6KB2
SCEL
SERF1A
SH3GL2
SH3GL3
SKA3
SMTNL2
SPATS2
SQSTM1
STAC
STK24
STK25
STK3
STK40
STN1
STRBP
STUB1
SUPT4H1
SYNJ1
TAOK3
TAS2R60
TBC1D22B
TCEA2
TCP10L
TGIF2LX
TRAF2
TTC27
TTLL1
TUBA1A
UBXN10
UFD1
UQCRB
USP39
VASH2
VGLL4
VN1R1
WSB1
WT1-AS
XIRP2
ZAP70
ZFAND5
ZMYM5
ZRANB2
63 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EML1
GEMIN7
GRM7
GSK3B
GZMB
HDAC6
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
PAFAH1B1
PLA2G7
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
TAOK2
TBCB
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
120892
7846
HPRD ID
10613
03959
Ensembl ID
ENSG00000188906
ENSG00000167552
Uniprot IDs
Q17RV3
Q5S007
Q71U36
PDB IDs
2ZEJ
3D6T
5MY9
5MYC
6DLO
6DLP
6OJE
6OJF
6VNO
6VP6
6VP7
6XR4
5JCO
6J8F
6WSL
7C1M
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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