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LRRK2 and TRAF2
Data Source:
BioGRID
(enzymatic study)
LRRK2
TRAF2
Description
leucine rich repeat kinase 2
TNF receptor associated factor 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Plasma Membrane
Microvillus
Inclusion Body
Axon
Dendrite
Growth Cone
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Membrane Raft
Extracellular Exosome
Endoplasmic Reticulum Exit Site
Multivesicular Body, Internal Vesicle
Postsynapse
Glutamatergic Synapse
Caveola Neck
Presynaptic Cytosol
Ribonucleoprotein Complex
Wnt Signalosome
Ubiquitin Ligase Complex
Tumor Necrosis Factor Receptor Superfamily Complex
Nucleoplasm
Cytosol
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Vesicle Membrane
CD40 Receptor Complex
Membrane Raft
TRAF2-GSTP1 Complex
Plasma Membrane Signaling Receptor Complex
IRE1-TRAF2-ASK1 Complex
Molecular Function
SNARE Binding
Magnesium Ion Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine Phosphatase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Microtubule Binding
Tubulin Binding
Kinase Activity
Syntaxin-1 Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Small GTPase Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Co-receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Beta-catenin Destruction Complex Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
CD40 Receptor Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein-macromolecule Adaptor Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Tumor Necrosis Factor Binding
Protein-containing Complex Binding
Sphingolipid Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Protein Dephosphorylation
Protein Import Into Nucleus
Endocytosis
Autophagy
Response To Oxidative Stress
Mitochondrion Organization
Endoplasmic Reticulum Organization
Golgi Organization
Lysosome Organization
Signal Transduction
Spermatogenesis
Neuromuscular Junction Development
Determination Of Adult Lifespan
Cellular Response To Starvation
Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Regulation Of Neuron Maturation
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Striatum Development
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Lysosomal Lumen PH
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
GTP Metabolic Process
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Mitochondrion Localization
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Protein Localization To Endoplasmic Reticulum Exit Site
Neuron Death
Cellular Response To Manganese Ion
Cellular Response To Organic Cyclic Compound
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Excitatory Postsynaptic Potential
Neuron Projection Arborization
Positive Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Histone Deacetylase Activity
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Positive Regulation Of Microglial Cell Activation
Wnt Signalosome Assembly
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of CAMKK-AMPK Signaling Cascade
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Immunoglobulin Production
Positive Regulation Of T Cell Cytokine Production
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Deubiquitination
Protein Catabolic Process
Positive Regulation Of Interleukin-2 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Protein-containing Complex Assembly
Response To Endoplasmic Reticulum Stress
Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of JNK Cascade
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Protein-containing Complex Assembly
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K63-linked Ubiquitination
Death-inducing Signaling Complex Assembly
Cellular Response To Nitric Oxide
Programmed Necrotic Cell Death
Negative Regulation Of Neuron Death
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of I-kappaB Phosphorylation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
PTK6 promotes HIF1A stabilization
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
Dimerization of procaspase-8
TNF signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
Defective RIPK1-mediated regulated necrosis
Drugs
Fostamatinib
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
21102463
)
Daytime sleep phenotypes (
27126917
)
Inflammatory bowel disease (
28067908
23128233
)
Leprosy (
25642632
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
32888494
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
25064009
31660654
27182965
24842889
28892059
22438815
28011712
21738487
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Platelet distribution width (
32888494
)
Interacting Genes
144 interacting genes:
ABLIM1
ACTB
AFF4
AHCYL1
AHDC1
AKT1
ANKS4B
APEX2
APP
ARFGAP1
ARHGEF7
AURKB
BAG1
BAG2
BAG3
C18orf25
C1orf87
CAMK1D
CBLB
CCDC43
CDC42EP3
CDKL3
CETN3
CHGB
CRMP1
CUEDC1
CXCL11
CYREN
DBF4B
DDIT4
DIDO1
DUX3
DVL1
DVL2
DVL3
DYRK2
E2F4
ECHS1
EIF4EBP1
ENKUR
ESRRG
FAM184A
FAM47B
FAM90A1
FANCM
FCHSD1
GTSF1
HIF1A
HSPD1
ITGB3BP
JHY
KCTD18
KDM4D
KLC2
L3MBTL3
LARP4
LARP7
LATS1
LGALS8
LINC01139
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MATK
MBP
MLLT3
MRGBP
MRPL19
MRPL28
MTA1
MYL9
NCBP3
NDUFAF7
NEK1
NSL1
PADI4
PDCL
PHF20L1
PIK3CB
PIK3R1
PLK1
POLR2M
POU5F1
PPP1R8
PRKCZ
PSME3IP1
PTPN23
RAB11FIP2
RAD51AP1
RALYL
RAPGEF4
RASL11B
RBIS
RHBDD1
RIPK2
RIT1
RPAP3
RPS6KB2
SCEL
SERF1A
SH3GL2
SH3GL3
SKA3
SMTNL2
SPATS2
SQSTM1
STAC
STK24
STK25
STK3
STK40
STN1
STRBP
STUB1
SUPT4H1
SYNJ1
TAOK3
TAS2R60
TBC1D22B
TCEA2
TCP10L
TGIF2LX
TRAF2
TTC27
TTLL1
TUBA1A
UBXN10
UFD1
UQCRB
USP39
VASH2
VGLL4
VN1R1
WSB1
WT1-AS
XIRP2
ZAP70
ZFAND5
ZMYM5
ZRANB2
378 interacting genes:
AASDHPPT
ABLIM1
ACTN3
AFF4
AGR2
AIMP2
AKR1B15
ALPL
AMOTL2
ANKRD11
ANKRD36BP1
APEX2
APPL1
AQP1
ARHGEF6
ARNT2
ARSJ
ASCC1
ATXN1
ATXN7
AXIN1
BAHD1
BANP
BAZ2B
BCL10
BCL6
BECN1
BEX2
BEX3
BIRC2
BIRC3
BOD1L2
BYSL
C22orf15
C2CD6
CALCOCO2
CAPN15
CASP8
CASP8AP2
CATSPER1
CAV1
CBX8
CCDC130
CCDC187
CCDC198
CCDC33
CCHCR1
CCNJL
CD27
CD40
CDC20B
CDC37
CDC42
CDCA3
CDK18
CDK9
CDKN1B
CEP57L1
CFAP57
CFLAR
CHCHD2
CHMP2B
CHUK
CREB5
CRY1
CRY2
CRYBA2
CTCF
CWF19L2
CYB5R2
CYLD
DDI1
DDX6
DGCR6
DLGAP5
DMTN
DTNB
DVL2
DVL3
EAF1
EBF2
EDAR
EDARADD
EEF1AKNMT
EFEMP1
EFHC1
EGFR
EIF4G1
ELOA2
ENKD1
EP300
EP400
ERN1
ETV6
EWSR1
EXOC3-AS1
FADD
FAM107A
FAM120B
FAM124B
FAM161A
FAM161B
FAM214B
FAM50B
FAM90A1
FAM9A
FARS2
FATE1
FBF1
FBXO28
FDXACB1
FLNA
FLYWCH1
FNDC11
FNDC3B
FOXN1
FXR2
GABPB1
GAS8
GCA
GCKR
GEM
GORASP2
GPANK1
GPKOW
GRIPAP1
GSE1
GSG1
GSTP1
GSTZ1
HENMT1
HINFP
HIVEP3
HOXA1
HOXB5
HSPA12B
IKBKB
IL15RA
IMPDH2
INO80B
IP6K3
IPO11
IQUB
IRF4
ITPK1
ITPRIPL1
JUN
KANK2
KANSL1
KIAA0408
KIAA1217
KIF26B
KIFC3
KLF3
LENG1
LINC02875
LNX1
LNX2
LONRF1
LRRK2
LTBR
LYSMD1
LZTS2
MACROH2A1
MALT1
MAP3K14
MAP3K5
MAP3K8
MAP4K2
MAP4K5
MAPK9
MAPRE1
MAST2
MBLAC1
MFAP1
MISP
MKRN3
MORN3
MOS
MPP3
MSRB2
MVP
MYO15B
NAB2
NATD1
NCAPH2
NEBL
NECAP2
NEDD9
NEK6
NFIL3
NFKBID
NGFR
NHSL2
NIF3L1
NMUR2
NOXA1
NR2C2
NR4A1
NRF1
NRIP1
NUDT16L1
NUDT18
PACS2
PALS1
PCGF2
PCGF5
PDLIM7
PDZD4
PEG3
PGBD1
PIAS2
PIBF1
PIN1
PKN1
POLR3C
POM121
PPL
PPP1R18
PPP1R32
PRKAB2
PRKRIP1
PRPF18
PSMB1
PSMD9
PSME3IP1
PSMF1
QARS1
QRICH1
RAD23A
RAD54L2
RALBP1
RANBP3
RAPGEF4
RASSF5
RBM41
RCOR3
RFX3
RGS14
RIBC2
RIN1
RIPK1
RIPK2
RIPK3
RIPPLY1
RIPPLY3
RNF146
RNF4
RRAS2
RSPH14
SAMD11
SCNM1
SETD5
SH2D4A
SHC3
SIAH2
SMG9
SMURF2
SNAI1
SNRNP25
SOX13
SOX30
SOX5
SOX9
SPATA2
SPG21
SPHK1
SPRY2
SUMO1
SUMO1P1
SYT17
TAB1
TAB2
TAB3
TANK
TAOK3
TBK1
TCAF1
TCEA2
TCEANC
TCL1A
TDP2
TEKT3
THAP7
THOP1
TICAM1
TIFA
TIGD4
TLE5
TNF
TNFAIP3
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF25
TNFRSF4
TNFRSF8
TNFRSF9
TNFSF4
TNFSF9
TNIK
TRADD
TRAF1
TRAF3
TRAF3IP2
TRAF5
TRAF6
TRAIP
TRIM14
TRIM31
TRIM37
TRIM42
TRIM50
TROAP
TRPC4AP
TRPT1
TSGA10IP
TSHZ2
TSHZ3
TSSC4
TTC23
TXN
UBC
UBE2D1
UBE2D2
UBE2I
UBE2N
UBE2V1
UBE2V2
UBQLN4
UBXN11
USF1
USP2
USP4
USP53
USP7
UTP14C
UTP23
VEZF1
VWA2
WASF1
YES1
ZBTB16
ZBTB24
ZBTB25
ZBTB43
ZBTB49
ZC2HC1C
ZFAND6
ZKSCAN3
ZMAT2
ZMYM5
ZNF205
ZNF250
ZNF35
ZNF410
ZNF417
ZNF438
ZNF488
ZNF544
ZNF572
ZNF574
ZNF646
ZNF648
ZNF655
ZNF662
ZNF688
ZNF774
ZSCAN23
ZSCAN32
ZSWIM3
ZZZ3
Entrez ID
120892
7186
HPRD ID
10613
03538
Ensembl ID
ENSG00000188906
ENSG00000127191
Uniprot IDs
Q17RV3
Q5S007
A0A024R8H5
Q12933
PDB IDs
2ZEJ
3D6T
5MY9
5MYC
6DLO
6DLP
6OJE
6OJF
6VNO
6VP6
6VP7
6XR4
1CA4
1CA9
1CZY
1CZZ
1D00
1D01
1D0A
1D0J
1F3V
1QSC
3KNV
3M06
3M0A
3M0D
Enriched GO Terms of Interacting Partners
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