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LRRK2 and KDM4D
Data Source:
BioGRID
(pull down)
LRRK2
KDM4D
Description
leucine rich repeat kinase 2
lysine demethylase 4D
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Lysosome
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Plasma Membrane
Microvillus
Inclusion Body
Axon
Dendrite
Growth Cone
Synaptic Vesicle Membrane
Cytoplasmic Vesicle
Mitochondrial Membrane
Cytoplasmic Side Of Mitochondrial Outer Membrane
Dendrite Cytoplasm
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Perikaryon
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Membrane Raft
Extracellular Exosome
Endoplasmic Reticulum Exit Site
Multivesicular Body, Internal Vesicle
Postsynapse
Glutamatergic Synapse
Caveola Neck
Presynaptic Cytosol
Ribonucleoprotein Complex
Wnt Signalosome
Nucleus
Nucleoplasm
Pericentric Heterochromatin
Site Of Double-strand Break
Blood Microparticle
Molecular Function
SNARE Binding
Magnesium Ion Binding
Actin Binding
GTPase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine Phosphatase Activity
GTPase Activator Activity
Protein Binding
ATP Binding
GTP Binding
Microtubule Binding
Tubulin Binding
Kinase Activity
Syntaxin-1 Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Small GTPase Binding
GTP-dependent Protein Kinase Activity
Peroxidase Inhibitor Activity
Co-receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Kinase A Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Beta-catenin Destruction Complex Binding
Damaged DNA Binding
Protein Binding
Chromatin DNA Binding
Histone Demethylase Activity
Histone Demethylase Activity (H3-K9 Specific)
Metal Ion Binding
Dioxygenase Activity
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Protein Dephosphorylation
Protein Import Into Nucleus
Endocytosis
Autophagy
Response To Oxidative Stress
Mitochondrion Organization
Endoplasmic Reticulum Organization
Golgi Organization
Lysosome Organization
Signal Transduction
Spermatogenesis
Neuromuscular Junction Development
Determination Of Adult Lifespan
Cellular Response To Starvation
Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Protein Kinase A Signaling
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Regulation Of Neuron Maturation
Negative Regulation Of Macroautophagy
Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Striatum Development
Olfactory Bulb Development
Tangential Migration From The Subventricular Zone To The Olfactory Bulb
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of GTPase Activity
Cellular Response To Oxidative Stress
Cellular Protein Localization
Intracellular Signal Transduction
Regulation Of Kidney Size
Exploration Behavior
Locomotory Exploration Behavior
Regulation Of Lysosomal Lumen PH
Regulation Of Locomotion
Regulation Of Membrane Potential
Positive Regulation Of Programmed Cell Death
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
GTP Metabolic Process
Protein Autophosphorylation
Intracellular Distribution Of Mitochondria
Neuron Projection Morphogenesis
Mitochondrion Localization
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Regulation Of Mitochondrial Depolarization
Regulation Of Synaptic Transmission, Glutamatergic
Canonical Wnt Signaling Pathway
Excitatory Postsynaptic Potential
Regulation Of Dopamine Receptor Signaling Pathway
Positive Regulation Of Dopamine Receptor Signaling Pathway
Regulation Of ER To Golgi Vesicle-mediated Transport
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Dendritic Spine Morphogenesis
Protein Localization To Mitochondrion
Protein Localization To Endoplasmic Reticulum Exit Site
Neuron Death
Cellular Response To Manganese Ion
Cellular Response To Organic Cyclic Compound
Reactive Oxygen Species Metabolic Process
Regulation Of Mitochondrial Fission
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Excitatory Postsynaptic Potential
Neuron Projection Arborization
Positive Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Histone Deacetylase Activity
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Regulation Of Neuroblast Proliferation
Regulation Of Synaptic Vesicle Transport
Negative Regulation Of Late Endosome To Lysosome Transport
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion
Cellular Response To Dopamine
Positive Regulation Of Microglial Cell Activation
Wnt Signalosome Assembly
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of CAMKK-AMPK Signaling Cascade
Regulation Of Branching Morphogenesis Of A Nerve
Regulation Of Synaptic Vesicle Exocytosis
Double-strand Break Repair Via Homologous Recombination
Regulation Of Protein Phosphorylation
Chromatin Remodeling
Histone H3-K9 Demethylation
Positive Regulation Of Chromatin Binding
Cellular Response To Ionizing Radiation
Negative Regulation Of Histone H3-K9 Trimethylation
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
PTK6 promotes HIF1A stabilization
HDMs demethylate histones
Drugs
Fostamatinib
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) (
26252872
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
21102463
)
Daytime sleep phenotypes (
27126917
)
Inflammatory bowel disease (
28067908
23128233
)
Leprosy (
25642632
)
Low density lipoprotein cholesterol levels (
32154731
)
Mean platelet volume (
32888494
)
Obesity-related traits (
23251661
)
Parkinson's disease (
21292315
19915576
25064009
31660654
27182965
24842889
28892059
22438815
28011712
21738487
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Diabetic kidney disease (
26305897
)
Interacting Genes
144 interacting genes:
ABLIM1
ACTB
AFF4
AHCYL1
AHDC1
AKT1
ANKS4B
APEX2
APP
ARFGAP1
ARHGEF7
AURKB
BAG1
BAG2
BAG3
C18orf25
C1orf87
CAMK1D
CBLB
CCDC43
CDC42EP3
CDKL3
CETN3
CHGB
CRMP1
CUEDC1
CXCL11
CYREN
DBF4B
DDIT4
DIDO1
DUX3
DVL1
DVL2
DVL3
DYRK2
E2F4
ECHS1
EIF4EBP1
ENKUR
ESRRG
FAM184A
FAM47B
FAM90A1
FANCM
FCHSD1
GTSF1
HIF1A
HSPD1
ITGB3BP
JHY
KCTD18
KDM4D
KLC2
L3MBTL3
LARP4
LARP7
LATS1
LGALS8
LINC01139
LRP6
MAP1B
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAPT
MATK
MBP
MLLT3
MRGBP
MRPL19
MRPL28
MTA1
MYL9
NCBP3
NDUFAF7
NEK1
NSL1
PADI4
PDCL
PHF20L1
PIK3CB
PIK3R1
PLK1
POLR2M
POU5F1
PPP1R8
PRKCZ
PSME3IP1
PTPN23
RAB11FIP2
RAD51AP1
RALYL
RAPGEF4
RASL11B
RBIS
RHBDD1
RIPK2
RIT1
RPAP3
RPS6KB2
SCEL
SERF1A
SH3GL2
SH3GL3
SKA3
SMTNL2
SPATS2
SQSTM1
STAC
STK24
STK25
STK3
STK40
STN1
STRBP
STUB1
SUPT4H1
SYNJ1
TAOK3
TAS2R60
TBC1D22B
TCEA2
TCP10L
TGIF2LX
TRAF2
TTC27
TTLL1
TUBA1A
UBXN10
UFD1
UQCRB
USP39
VASH2
VGLL4
VN1R1
WSB1
WT1-AS
XIRP2
ZAP70
ZFAND5
ZMYM5
ZRANB2
4 interacting genes:
CEP76
LRRK2
PPP1CC
TP53
Entrez ID
120892
55693
HPRD ID
10613
17169
Ensembl ID
ENSG00000188906
ENSG00000186280
Uniprot IDs
Q17RV3
Q5S007
Q6B0I6
PDB IDs
2ZEJ
3D6T
5MY9
5MYC
6DLO
6DLP
6OJE
6OJF
6VNO
6VP6
6VP7
6XR4
3DXT
3DXU
4D6Q
4D6R
4D6S
4HON
4HOO
5F5A
5F5C
5FP4
5FP7
5FP8
5FP9
5FPA
5FPB
5PH0
5PH1
5PH2
5PH3
5PH4
5PH5
5PH6
5PH7
5PH8
5PH9
5PHA
5PHB
5PHC
5PHD
5PHE
5PHF
5PHG
5PHH
5PHI
5PHJ
5PHK
5PHL
5PHM
5PHN
5PHO
5PHP
5PHQ
5PHR
5PHS
5PHT
5PHU
5PHV
5PHW
5PHX
5PHY
5PHZ
5PI0
5PI1
5PI2
5PI3
5PI4
5PI5
5PI6
5PI7
5PI8
5PI9
5PIA
5PIB
5PIC
5PID
5PIE
5PIF
5PIG
5PIH
5PII
5PIJ
5PIK
5PIL
5PIM
5PIN
5PIO
5PIP
5PIQ
5PIR
5PIS
5PIT
5PIU
5PIV
5PIW
5PIX
5PIY
5PIZ
5PJ0
5PJ1
5PJ2
5PJ3
5PJ4
5PJ5
5PJ6
5PJ7
5PJ8
5PJ9
5PJA
5PJB
5PJC
5PJD
5PJE
5PJF
5PJG
5PJH
5PJI
5PJJ
5PJK
5PJL
5PJM
5PJN
5PJO
5PJP
5PJQ
5PJR
5PJS
5PJT
5PJU
5PJV
5PJW
5PJX
5PJY
5PJZ
5PK0
5PK1
5PK2
5PK3
5PK4
5PK5
5PK6
5PK7
5PK8
5PK9
5PKA
5PKB
5PKC
5PKD
5PKE
5PKF
5PKG
5PKH
5PKI
5PKJ
5PKK
5PKL
5PKM
5PKN
5PKO
5PKP
5PKQ
5PKR
5PKS
5PKT
5PKU
5PKV
5PKW
5PKX
5PKY
5PKZ
5PL0
5PL1
5PL2
5PL3
5PL4
5PL5
5PL6
5PL7
5PL8
5PL9
5PLA
5PLB
5PLC
5PLD
5PLE
5PLF
5PLG
5PLH
5PLI
5PLJ
5PLK
5PLL
5PLM
5PLN
5PLO
5PLP
5PLQ
5PLR
5PLS
5PLT
5PLU
5PLV
5PLW
5PLX
5PLY
5PLZ
5PM0
5PM1
5PM2
5PM3
5PM4
5PM5
5PM6
5PM7
5PM8
5PM9
5PMA
5PMB
5PMC
5PMD
5PME
5PMF
5PMG
5PMH
5PMI
5PMJ
5PMK
5PML
5PMM
5PMN
5PMO
5PMP
5PMQ
5PMR
5PMS
5PMT
5PMU
5PMV
5PMW
5PMX
5PMY
5PMZ
5PN0
5PN1
5PN2
5PN3
5PN4
5PN5
5PN6
5PN7
5PN8
5PN9
5PNA
5PNB
5PNC
5PND
5PNE
5PNF
5PNG
5PNH
5PNI
5PNJ
5PNK
5PNL
5PNM
5PNN
5PNO
5PNP
5PNQ
5PNR
5PNS
5PNU
5PNV
5PNW
6ETE
6ETG
6ETS
6ETT
6ETU
6ETV
6ETW
6F5Q
6F5R
6F5S
6F5T
6H0W
6H0X
6H0Y
6H0Z
6H10
6H11
Enriched GO Terms of Interacting Partners
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