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BAG4 and TLE5
Data Source:
BioGRID
(two hybrid)
BAG4
TLE5
Description
BAG cochaperone 4
TLE family member 5, transcriptional modulator
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Nucleus
Transcription Regulator Complex
Molecular Function
Adenyl-nucleotide Exchange Factor Activity
RNA Binding
Protein Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Chaperone Binding
Transcription Corepressor Activity
Protein Binding
Repressing Transcription Factor Binding
Biological Process
Protein Folding
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Peptidyl-serine Phosphorylation
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Adhesion
Protein Stabilization
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Protein Localization To Plasma Membrane
Negative Regulation Of MRNA Modification
Ruffle Assembly
Regulation Of Cellular Response To Heat
Negative Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Multicellular Organism Development
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Regulation Of Growth
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Response To Cytokine Stimulus
Response To Interleukin-1
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Anoikis
Pathways
Regulation of HSF1-mediated heat shock response
Signaling by FGFR1 in disease
TNF signaling
Signaling by plasma membrane FGFR1 fusions
Repression of WNT target genes
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Schizophrenia (
28991256
29483656
)
Interacting Genes
117 interacting genes:
ABI2
ACOT7
ADAMTSL4
ALG13
APOBEC1
ARID5A
ATAD2
ATP23
BAP1
BCAS3
BCL2
BCL6B
BEX1
BLZF1
C3orf38
CASP2
CASZ1
CBFA2T2
CCL5
DDIT4L
DIRAS3
DZIP3
EFEMP1
EPSTI1
ERRFI1
FAM214B
FAM222B
FARS2
FTH1
FYN
GLCE
GPANK1
GPS2
GRAP2
HOXA1
HSPA1A
HSPA1B
HSPA1L
HSPA2
HSPA6
HSPA8
IL13RA2
IL24
IST1
ITIH5
KCTD6
KCTD7
KIF5B
KLK5
KLK7
KLK9
KRTAP13-1
KRTAP13-4
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP6-3
LASP1
LRATD2
LYPD3
MAGED1
MEI4
MRC2
MTA3
MYOZ1
MYOZ3
MYPOP
NAT2
ODF1
ODF3L1
P4HA3
PDCD6
PDLIM2
PEF1
PGRMC2
PHF19
PLAC8
PPIL6
PPP1R32
PRDM14
PSMB5
PYCR3
RAMAC
RASL10B
RHOBTB2
RNF20
RPL22
RUNX1
SAMD4A
SAXO1
SCGB3A1
SH3RF2
SIAH1
SNRPB
SNRPC
SS18L1
SUOX
TBC1D3B
TBC1D3G
TBC1D7
TCL1B
TEKT5
TFAP2D
THRSP
TINAGL1
TLE5
TNFRSF1A
TNFRSF25
TRAPPC6A
TSG101
UNKL
USP22
VPS37C
ZBTB45
ZBTB5
ZIM2
362 interacting genes:
ABI2
AEN
AGR2
AKAP8L
ANAPC11
ANKRD11
AR
ARHGAP32
ASB3
ATN1
ATP6V0D1
BAG4
BAHD1
BCL6
BHLHE40
BIRC7
BPIFA1
BYSL
C10orf55
C11orf1
C14orf119
C19orf54
C1orf109
C1orf216
C1orf94
C2CD6
C7orf57
CABP2
CABP4
CABP5
CALCOCO2
CAPN1
CARD9
CCDC120
CCDC57
CCL7
CCNJL
CCNK
CCNO
CFAP206
CIB3
CLIC3
CLIP3
CNFN
COA7
CPSF7
CRACR2A
CRX
CSNK2A1
CSTF2
CSTF2T
CT55
CTBP2
CYSRT1
DAZAP2
DCUN1D1
DDX6
DGCR6
DIP2A
DMRT2
DMRT3
DMRTB1
DNMT3L
DOK6
DVL2
DVL3
DYDC1
EAF1
EAF2
EFEMP2
EFHC1
EIF1AD
EIF4E2
ERF
EXOSC5
EYA2
FAM124A
FAM124B
FAM168B
FAM214B
FAM217B
FAM90A1
FANCG
FBF1
FCHSD2
FHL3
FOSB
FOXD2
FOXN1
FOXP2
FRS3
FSD2
GABARAP
GATA1
GCC1
GEM
GFAP
GFI1B
GIGYF1
GLIS2
GLRX3
GOLGA2
GOLGA6L9
GORASP2
GPANK1
GPATCH2L
GRAP2
GRB2
GRN
GTF2E1
GYS1
HDAC4
HDHD3
HELT
HEXIM2
HGS
HHEX
HMGB1
HNF1A
HNRNPF
HNRNPH2
HNRNPK
HNRNPLL
HOMEZ
HOXA1
HOXB5
HOXC8
HOXC9
IKZF3
INO80B
INO80E
INPP5J
IRX2
IRX6
KANK2
KDM1A
KIFC3
KLF1
KLF4
KLHDC7B
KRT13
KRT15
KRT31
KRT34
KRT35
KRT40
KRTAP10-11
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
L3MBTL2
LDLR
LDOC1
LENG8
LHX3
LINC00526
LMO1
LMO2
LMO4
LSM2
LZTS2
MAGOHB
MAPK1
MAPK14
MAPRE3
MBNL1
MCRS1
MDFI
MED12L
MED25
MED31
MED4
MEIS3
MFAP1
MIA2
MIIP
MKRN3
MLH1
MLLT6
MLX
MORF4L1
MORF4L2
MSS51
MSX1
MSX2
MTUS2
MVP
MYF5
MYH7B
MYO15B
MYOG
NAB2
NAF1
NBPF19
NCDN
NDOR1
NDUFB7
NEK6
NOTCH2NLA
NTAQ1
NUDT22
NUTF2
NUTM1
OLIG3
OSGIN1
OXER1
P4HA3
PARVG
PATZ1
PAX8
PAX9
PCBP1
PCSK5
PFDN5
PHF1
PICK1
PITX1
PITX2
PLAGL1
POLR1C
POU2F1
PPP1R16A
PPP1R16B
PRDM1
PRDM14
PRDM6
PRKAA1
PRKAA2
PRKAB2
PROP1
PRPF31
PRR3
PRR35
PSMB1
PSMB4
PSMF1
PTRH2
QARS1
RAD51D
RBM10
RBPMS
REL
RELA
RFX6
RHOXF2
RIBC1
RIMBP3
RIPPLY1
RNF31
RORB
RPL18A
RUNX1
RUSC1
SAT1
SCNM1
SDCBP
SERTAD3
SET
SF3B4
SH2B2
SH3GL3
SHFL
SHISA6
SIX1
SIX2
SIX3
SIX6
SKIL
SMAD3
SMAD4
SMARCB1
SMARCD1
SNCAIP
SNRPA
SNRPC
SOHLH1
SOX5
SPATA25
SPG21
SRPK2
SSC4D
STK16
STX11
SUFU
SUPT5H
TBX3
TBX6
TCEANC
TCF4
TCF7L2
TEAD4
TENT5B
TEX37
TFAP2D
THAP7
TIGD3
TMCC2
TNS2
TOX3
TRAF1
TRAF2
TRIB3
TRIM26
TRIM27
TRIM41
TRIP6
TRMT2A
TSC1
TSC22D4
TSEN15
TSGA10
TSGA10IP
TSSK3
TTC23
U2AF2
UBAP2
UBE2H
UBL5
UBXN11
USP2
USP54
VEZF1
VGLL1
VIM
VPS37B
VPS37C
YPEL3
YTHDF1
ZBTB16
ZBTB24
ZBTB47
ZFHX3
ZGPAT
ZIC1
ZMYND12
ZNF330
ZNF34
ZNF383
ZNF408
ZNF414
ZNF417
ZNF467
ZNF48
ZNF503
ZNF524
ZNF576
ZNF688
ZNF792
ZNF835
ZRANB1
Entrez ID
9530
166
HPRD ID
04861
02556
Ensembl ID
ENSG00000156735
ENSG00000104964
Uniprot IDs
O95429
Q08117
Q8WY48
PDB IDs
1M62
1M7K
Enriched GO Terms of Interacting Partners
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