BAG4 and KLK7

Data Source:
BioGRID (two hybrid)

		BAG4	KLK7
Description		BAG cochaperone 4	kallikrein related peptidase 7
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Extracellular Region Extracellular Space Secretory Granule Epidermal Lamellar Body
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity RNA Binding Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Chaperone Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Stabilization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly
Pathways		Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions	Degradation of the extracellular matrix
Drugs			L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		117 interacting genes: ABI2 ACOT7 ADAMTSL4 ALG13 APOBEC1 ARID5A ATAD2 ATP23 BAP1 BCAS3 BCL2 BCL6B BEX1 BLZF1 C3orf38 CASP2 CASZ1 CBFA2T2 CCL5 DDIT4L DIRAS3 DZIP3 EFEMP1 EPSTI1 ERRFI1 FAM214B FAM222B FARS2 FTH1 FYN GLCE GPANK1 GPS2 GRAP2 HOXA1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IL13RA2 IL24 IST1 ITIH5 KCTD6 KCTD7 KIF5B KLK5 KLK7 KLK9 KRTAP13-1 KRTAP13-4 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP6-3 LASP1 LRATD2 LYPD3 MAGED1 MEI4 MRC2 MTA3 MYOZ1 MYOZ3 MYPOP NAT2 ODF1 ODF3L1 P4HA3 PDCD6 PDLIM2 PEF1 PGRMC2 PHF19 PLAC8 PPIL6 PPP1R32 PRDM14 PSMB5 PYCR3 RAMAC RASL10B RHOBTB2 RNF20 RPL22 RUNX1 SAMD4A SAXO1 SCGB3A1 SH3RF2 SIAH1 SNRPB SNRPC SS18L1 SUOX TBC1D3B TBC1D3G TBC1D7 TCL1B TEKT5 TFAP2D THRSP TINAGL1 TLE5 TNFRSF1A TNFRSF25 TRAPPC6A TSG101 UNKL USP22 VPS37C ZBTB45 ZBTB5 ZIM2	10 interacting genes: APP BAG4 CCND1 CDSN CHEK2 PTPN1 PTPRJ STK11 TGFB1 WT1
Entrez ID		9530	5650
HPRD ID		04861	05115
Ensembl ID		ENSG00000156735	ENSG00000169035
Uniprot IDs		O95429	A0A024R4H6 B4DHX9 P49862
PDB IDs		1M62 1M7K	2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK 6SHH 6SHI 6SJU 6Y4S
Enriched GO Terms of Interacting Partners?
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