TLE5 and SMARCB1

Data Source:
BioGRID (two hybrid)

		TLE5	SMARCB1
Description		TLE family member 5, transcriptional modulator	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex	Nuclear Chromosome Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus SWI/SNF Complex Protein-containing Complex Brahma Complex Intracellular Membrane-bounded Organelle NpBAF Complex NBAF Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Tat Protein Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	RNA Polymerase I Preinitiation Complex Assembly Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cell Cycle Nervous System Development DNA Integration Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K9 Dimethylation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Histone H4-K16 Acetylation
Pathways		Repression of WNT target genes	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional shortening ( 29403010) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) N-glycan levels ( 31163085)
Interacting Genes		362 interacting genes: ABI2 AEN AGR2 AKAP8L ANAPC11 ANKRD11 AR ARHGAP32 ASB3 ATN1 ATP6V0D1 BAG4 BAHD1 BCL6 BHLHE40 BIRC7 BPIFA1 BYSL C10orf55 C11orf1 C14orf119 C19orf54 C1orf109 C1orf216 C1orf94 C2CD6 C7orf57 CABP2 CABP4 CABP5 CALCOCO2 CAPN1 CARD9 CCDC120 CCDC57 CCL7 CCNJL CCNK CCNO CFAP206 CIB3 CLIC3 CLIP3 CNFN COA7 CPSF7 CRACR2A CRX CSNK2A1 CSTF2 CSTF2T CT55 CTBP2 CYSRT1 DAZAP2 DCUN1D1 DDX6 DGCR6 DIP2A DMRT2 DMRT3 DMRTB1 DNMT3L DOK6 DVL2 DVL3 DYDC1 EAF1 EAF2 EFEMP2 EFHC1 EIF1AD EIF4E2 ERF EXOSC5 EYA2 FAM124A FAM124B FAM168B FAM214B FAM217B FAM90A1 FANCG FBF1 FCHSD2 FHL3 FOSB FOXD2 FOXN1 FOXP2 FRS3 FSD2 GABARAP GATA1 GCC1 GEM GFAP GFI1B GIGYF1 GLIS2 GLRX3 GOLGA2 GOLGA6L9 GORASP2 GPANK1 GPATCH2L GRAP2 GRB2 GRN GTF2E1 GYS1 HDAC4 HDHD3 HELT HEXIM2 HGS HHEX HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPK HNRNPLL HOMEZ HOXA1 HOXB5 HOXC8 HOXC9 IKZF3 INO80B INO80E INPP5J IRX2 IRX6 KANK2 KDM1A KIFC3 KLF1 KLF4 KLHDC7B KRT13 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP10-11 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 L3MBTL2 LDLR LDOC1 LENG8 LHX3 LINC00526 LMO1 LMO2 LMO4 LSM2 LZTS2 MAGOHB MAPK1 MAPK14 MAPRE3 MBNL1 MCRS1 MDFI MED12L MED25 MED31 MED4 MEIS3 MFAP1 MIA2 MIIP MKRN3 MLH1 MLLT6 MLX MORF4L1 MORF4L2 MSS51 MSX1 MSX2 MTUS2 MVP MYF5 MYH7B MYO15B MYOG NAB2 NAF1 NBPF19 NCDN NDOR1 NDUFB7 NEK6 NOTCH2NLA NTAQ1 NUDT22 NUTF2 NUTM1 OLIG3 OSGIN1 OXER1 P4HA3 PARVG PATZ1 PAX8 PAX9 PCBP1 PCSK5 PFDN5 PHF1 PICK1 PITX1 PITX2 PLAGL1 POLR1C POU2F1 PPP1R16A PPP1R16B PRDM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRKAB2 PROP1 PRPF31 PRR3 PRR35 PSMB1 PSMB4 PSMF1 PTRH2 QARS1 RAD51D RBM10 RBPMS REL RELA RFX6 RHOXF2 RIBC1 RIMBP3 RIPPLY1 RNF31 RORB RPL18A RUNX1 RUSC1 SAT1 SCNM1 SDCBP SERTAD3 SET SF3B4 SH2B2 SH3GL3 SHFL SHISA6 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMAD4 SMARCB1 SMARCD1 SNCAIP SNRPA SNRPC SOHLH1 SOX5 SPATA25 SPG21 SRPK2 SSC4D STK16 STX11 SUFU SUPT5H TBX3 TBX6 TCEANC TCF4 TCF7L2 TEAD4 TENT5B TEX37 TFAP2D THAP7 TIGD3 TMCC2 TNS2 TOX3 TRAF1 TRAF2 TRIB3 TRIM26 TRIM27 TRIM41 TRIP6 TRMT2A TSC1 TSC22D4 TSEN15 TSGA10 TSGA10IP TSSK3 TTC23 U2AF2 UBAP2 UBE2H UBL5 UBXN11 USP2 USP54 VEZF1 VGLL1 VIM VPS37B VPS37C YPEL3 YTHDF1 ZBTB16 ZBTB24 ZBTB47 ZFHX3 ZGPAT ZIC1 ZMYND12 ZNF330 ZNF34 ZNF383 ZNF408 ZNF414 ZNF417 ZNF467 ZNF48 ZNF503 ZNF524 ZNF576 ZNF688 ZNF792 ZNF835 ZRANB1	112 interacting genes: ABI2 AKT1 APP ARL11 ATP5F1A BCL2L11 BHLHE40 BLZF1 CALR CAMK2D CCDC120 CCDC33 CD69 CDC23 CDX2 CEBPB CHFR CXCL11 CYB5D2 DNAJA3 DPH6 FAM90A1 FAM9B FUS GADD45G GATA1 GFAP GOLGA2 HGS HNRNPM HOMEZ HOOK2 HSF2BP HSFY1 IHO1 IKZF3 IL16 KCTD9 KLC3 KLF1 KMT2B KMT2C KPNA6 KRT15 KRT19 KRT6A KRT6B KRT6C LDOC1 LENG8 LNX2 LY96 LZTS2 MAP1LC3B MAP3K20 MAPK8IP2 MBIP MCPH1 MECP2 MESD MIF4GD MRPL53 MXI1 MYC NCK2 NONO NR0B2 NR3C1 OSGIN1 OTX2 PDPK1 PICK1 PPP1CC PPP1R15A PRKAB2 PRMT5 PSMB1 RAN RB1 RELB RINT1 RPN1 RPS6KA5 RUSC1 RXRA SAXO1 SIN3B SMARCA4 SMARCC2 SMARCD1 SRC TACC2 TAF1D TASOR2 TEKT5 TFIP11 TLE5 TNFAIP1 TNRC6A TP53 TRIM14 TRIM27 TRIM35 TSC22D4 UBQLN4 VIM XPO1 YEATS4 ZC3H11A ZDHHC17 ZNF398 ZNF688
Entrez ID		166	6598
HPRD ID		02556	03364
Ensembl ID		ENSG00000104964	ENSG00000099956
Uniprot IDs		Q08117 Q8WY48	G5E975 Q12824 Q9H836
PDB IDs			5AJ1 5GJK 5L7A 5L7B 6AX5 6KAG 6KZ7 6LTH 6LTJ 6UCH
Enriched GO Terms of Interacting Partners?
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