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TLE5 and KRT40
Data Source:
BioGRID
(two hybrid, two hybrid)
TLE5
KRT40
Description
TLE family member 5, transcriptional modulator
keratin 40
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Transcription Regulator Complex
Cytosol
Intermediate Filament
Molecular Function
Transcription Corepressor Activity
Protein Binding
Repressing Transcription Factor Binding
Structural Molecule Activity
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Multicellular Organism Development
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Binding
Regulation Of Growth
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Response To Cytokine Stimulus
Response To Interleukin-1
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Anoikis
Keratinization
Cornification
Pathways
Repression of WNT target genes
Keratinization
Formation of the cornified envelope
Drugs
Diseases
GWAS
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Interacting Genes
362 interacting genes:
ABI2
AEN
AGR2
AKAP8L
ANAPC11
ANKRD11
AR
ARHGAP32
ASB3
ATN1
ATP6V0D1
BAG4
BAHD1
BCL6
BHLHE40
BIRC7
BPIFA1
BYSL
C10orf55
C11orf1
C14orf119
C19orf54
C1orf109
C1orf216
C1orf94
C2CD6
C7orf57
CABP2
CABP4
CABP5
CALCOCO2
CAPN1
CARD9
CCDC120
CCDC57
CCL7
CCNJL
CCNK
CCNO
CFAP206
CIB3
CLIC3
CLIP3
CNFN
COA7
CPSF7
CRACR2A
CRX
CSNK2A1
CSTF2
CSTF2T
CT55
CTBP2
CYSRT1
DAZAP2
DCUN1D1
DDX6
DGCR6
DIP2A
DMRT2
DMRT3
DMRTB1
DNMT3L
DOK6
DVL2
DVL3
DYDC1
EAF1
EAF2
EFEMP2
EFHC1
EIF1AD
EIF4E2
ERF
EXOSC5
EYA2
FAM124A
FAM124B
FAM168B
FAM214B
FAM217B
FAM90A1
FANCG
FBF1
FCHSD2
FHL3
FOSB
FOXD2
FOXN1
FOXP2
FRS3
FSD2
GABARAP
GATA1
GCC1
GEM
GFAP
GFI1B
GIGYF1
GLIS2
GLRX3
GOLGA2
GOLGA6L9
GORASP2
GPANK1
GPATCH2L
GRAP2
GRB2
GRN
GTF2E1
GYS1
HDAC4
HDHD3
HELT
HEXIM2
HGS
HHEX
HMGB1
HNF1A
HNRNPF
HNRNPH2
HNRNPK
HNRNPLL
HOMEZ
HOXA1
HOXB5
HOXC8
HOXC9
IKZF3
INO80B
INO80E
INPP5J
IRX2
IRX6
KANK2
KDM1A
KIFC3
KLF1
KLF4
KLHDC7B
KRT13
KRT15
KRT31
KRT34
KRT35
KRT40
KRTAP10-11
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
L3MBTL2
LDLR
LDOC1
LENG8
LHX3
LINC00526
LMO1
LMO2
LMO4
LSM2
LZTS2
MAGOHB
MAPK1
MAPK14
MAPRE3
MBNL1
MCRS1
MDFI
MED12L
MED25
MED31
MED4
MEIS3
MFAP1
MIA2
MIIP
MKRN3
MLH1
MLLT6
MLX
MORF4L1
MORF4L2
MSS51
MSX1
MSX2
MTUS2
MVP
MYF5
MYH7B
MYO15B
MYOG
NAB2
NAF1
NBPF19
NCDN
NDOR1
NDUFB7
NEK6
NOTCH2NLA
NTAQ1
NUDT22
NUTF2
NUTM1
OLIG3
OSGIN1
OXER1
P4HA3
PARVG
PATZ1
PAX8
PAX9
PCBP1
PCSK5
PFDN5
PHF1
PICK1
PITX1
PITX2
PLAGL1
POLR1C
POU2F1
PPP1R16A
PPP1R16B
PRDM1
PRDM14
PRDM6
PRKAA1
PRKAA2
PRKAB2
PROP1
PRPF31
PRR3
PRR35
PSMB1
PSMB4
PSMF1
PTRH2
QARS1
RAD51D
RBM10
RBPMS
REL
RELA
RFX6
RHOXF2
RIBC1
RIMBP3
RIPPLY1
RNF31
RORB
RPL18A
RUNX1
RUSC1
SAT1
SCNM1
SDCBP
SERTAD3
SET
SF3B4
SH2B2
SH3GL3
SHFL
SHISA6
SIX1
SIX2
SIX3
SIX6
SKIL
SMAD3
SMAD4
SMARCB1
SMARCD1
SNCAIP
SNRPA
SNRPC
SOHLH1
SOX5
SPATA25
SPG21
SRPK2
SSC4D
STK16
STX11
SUFU
SUPT5H
TBX3
TBX6
TCEANC
TCF4
TCF7L2
TEAD4
TENT5B
TEX37
TFAP2D
THAP7
TIGD3
TMCC2
TNS2
TOX3
TRAF1
TRAF2
TRIB3
TRIM26
TRIM27
TRIM41
TRIP6
TRMT2A
TSC1
TSC22D4
TSEN15
TSGA10
TSGA10IP
TSSK3
TTC23
U2AF2
UBAP2
UBE2H
UBL5
UBXN11
USP2
USP54
VEZF1
VGLL1
VIM
VPS37B
VPS37C
YPEL3
YTHDF1
ZBTB16
ZBTB24
ZBTB47
ZFHX3
ZGPAT
ZIC1
ZMYND12
ZNF330
ZNF34
ZNF383
ZNF408
ZNF414
ZNF417
ZNF467
ZNF48
ZNF503
ZNF524
ZNF576
ZNF688
ZNF792
ZNF835
ZRANB1
381 interacting genes:
ACSF3
ADAMTS1
ADAMTSL3
AEN
AGXT
AKAP17A
ALDH3B1
ANKRD36BP1
AP1M1
AQP1
AQP5
ARID5A
ARMC7
ARSI
ASMTL
ATPAF2
AVPI1
AXIN1
BAHD1
BARD1
BCAS2
BEX2
BMS1P1
BRME1
BYSL
C10orf62
C11orf87
C19orf73
C1orf109
C1orf216
C22orf46
C2CD6
C2orf68
C4orf45
C5orf60
C6orf226
C8orf48
CA6
CARD9
CATIP
CBX8
CCDC112
CCDC116
CCDC120
CCDC146
CCDC185
CCDC198
CCDC26
CCDC93
CCER1
CCHCR1
CCNG1
CD33
CDC20B
CDK18
CDK5R1
CELA2B
CEP57
CEP57L1
CFAP206
CHCHD2
CHCHD3
CHIC2
CLEC18A
CNNM3
CNTF
COL8A1
COMT
COX5A
CREB5
CRY2
CTSZ
CWF19L2
CYCS
CYTH4
DAAM2
DCDC2B
DCX
DDX6
DHX57
DLGAP2
DMRT3
DOCK2
DOCK8
DTNB
EIF4E2
ELOA
ENKD1
EXOC3-AS1
FADS2
FAM107A
FAM124B
FAM214A
FAM27E3
FAM71C
FAM74A4
FAM90A1
FARS2
FASLG
FBF1
FBXL18
FBXO34
FBXW5
FEZF1
FKBP1B
FNDC11
FOXB1
FRG1
GAD1
GADD45GIP1
GATA2
GATAD2A
GEM
GFOD1
GGN
GLIDR
GNAI2
GNE
GNG5
GOLGA6L2
GPATCH2L
GTF3C5
GUCD1
HAPLN2
HAUS1
HBA2
HBZ
HCK
HDAC4
HGS
HNRNPLL
HOXA1
HOXB9
HOXC8
HSD3B7
HSF4
HSPA12B
HSPD1
ING5
INO80B
INPP5D
IQUB
ISCU
ITGB4
ITGB5
JOSD1
KANK2
KAT5
KCTD9
KDM1A
KIFC3
KLHL38
KPNA2
KRT2
KRT20
KRT4
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT72
KRT75
KRT76
KRT8
KRT81
KRT82
KRT83
KRT85
KRT86
LAGE3
LCE3E
LENG1
LHX4
LIMS2
LIN37
LINC00636
LINC01588
LMF2
LMO1
LMO2
LMO4
LRCH4
MAB21L2
MAGOHB
MAPKBP1
MARK4
MED8
METTL17
MFAP1
MID2
MOB3C
MOBP
MOS
MRPL11
MRRF
MSRB3
MTA1
MXI1
MYPOP
NAB2
NAPRT
NDEL1
NEK6
NFKBID
NINJ1
NOL4L-DT
NPBWR2
NPPB
NR1D2
NXF1
ODAD4
OIP5
OPCML
OTUB2
PDLIM5
PGLS
PHF1
PHF21A
PHLDA1
PIGS
PIMREG
PIN1
PKD2
POLDIP3
POLL
POM121L8P
POP5
PPP1R18
PRAM1
PRKAA1
PRKAB2
PRPF18
PRPF31
PSMA1
PSMB1
PSMC5
PTGER3
PTPMT1
PXMP2
QPRT
RAB3IL1
RAB3IP
RAC1
RASSF5
RBM41
RCOR3
RECK
RGS8
RNF213
RNF6
RPL11
RSPH14
RTP5
RWDD2B
RXRB
SCAND1
SCOC
SEMA4C
SETD5
SH2D4A
SHC3
SHFL
SIRPA
SLC23A1
SLC25A10
SLIRP
SLU7
SMARCE1
SMCO4
SNAI1
SNHG11
SNRPB
SNW1
SPATA24
SPATC1L
SPEF1
SPG7
SRSF2
SSX2
SSX2IP
SUOX
SYT6
TACO1
TAPBPL
TBC1D16
TBC1D21
TBC1D22B
TCEA2
TCEANC
TCHP
TEAD4
THAP7
TIE1
TLE5
TMEM231
TMEM241
TMSB4X
TNIP3
TNNT1
TRAF4
TRIM42
TROAP
TRPV6
TSC22D4
TSGA10IP
TSHZ3
TTC23
TTC9C
TTLL10
TXLNA
TXN2
TXNDC5
TYK2
TYRO3
UACA
UBASH3A
UCMA
USHBP1
USP2
USP21
UTP14C
UTP23
UXT
VEZF1
WDR25
WT1
WT1-AS
ZBTB16
ZBTB24
ZBTB38
ZBTB42
ZC2HC1C
ZFHX3
ZFP1
ZFP2
ZFP69B
ZFYVE21
ZFYVE26
ZGPAT
ZMAT2
ZNF101
ZNF124
ZNF138
ZNF165
ZNF17
ZNF20
ZNF202
ZNF230
ZNF250
ZNF26
ZNF266
ZNF286A
ZNF317
ZNF319
ZNF329
ZNF337
ZNF408
ZNF410
ZNF417
ZNF438
ZNF439
ZNF446
ZNF488
ZNF490
ZNF564
ZNF569
ZNF575
ZNF580
ZNF581
ZNF587
ZNF625
ZNF655
ZNF688
ZNF697
ZNF702P
ZNF76
ZNF792
ZNF844
ZNRF2P1
ZSCAN21
Entrez ID
166
125115
HPRD ID
02556
08304
Ensembl ID
ENSG00000104964
ENSG00000204889
Uniprot IDs
Q08117
Q8WY48
Q6A162
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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