FHL5 and BBC3

Data Source:
BioGRID (two hybrid)

		FHL5	BBC3
Description		four and a half LIM domains 5	BCL2 binding component 3
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GO Annotations	Cellular Component	Nucleus Z Disc	Mitochondrion Lysosome
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding	Protein Binding ATPase Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Monocyte count ( 27863252) White blood cell count ( 32888494)
Interacting Genes		90 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FAM214B FAM71C FARS2 FEZF1 FHL2 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 PPP1R32 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF131 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1	14 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 FHL5 HGS HSD17B13 MCL1 MYPOP NDUFAB1 UBASH3B WDR5 ZNF438
Entrez ID		9457	27113
HPRD ID		05497	16165
Ensembl ID		ENSG00000112214	ENSG00000105327
Uniprot IDs		Q5TD97	Q96PG8 Q9BXH1
PDB IDs		1X68	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8 6TQP
Enriched GO Terms of Interacting Partners?
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