MUS81 and SLX4

Data Source:
HPRD (in vivo)

		MUS81	SLX4
Description		MUS81 structure-specific endonuclease subunit	SLX4 structure-specific endonuclease subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)	Type 2 diabetes ( 32499647)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		80198	84464
HPRD ID		09419	12537
Ensembl ID		ENSG00000172732	ENSG00000188827
Uniprot IDs		Q53ES5 Q96NY9	Q8IY92
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S	4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?