MUS81 and EME2

Data Source:
BioGRID (pull down)

		MUS81	EME2
Description		MUS81 structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Nucleus Holliday Junction Resolvase Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity	DNA Binding Endonuclease Activity Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	4 interacting genes: FAAP24 FANCM MEOX2 MUS81
Entrez ID		80198	197342
HPRD ID		09419	16859
Ensembl ID		ENSG00000172732	ENSG00000197774
Uniprot IDs		Q53ES5 Q96NY9	A4GXA9
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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