MUS81 and EME1

Data Source:
HPRD (in vitro)

		MUS81	EME1
Description		MUS81 structure-specific endonuclease subunit	essential meiotic structure-specific endonuclease 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Heterochromatin Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity	DNA Binding Endonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	6 interacting genes: APP DDB1 MUS81 SLX1A SLX4 SUMO2
Entrez ID		80198	146956
HPRD ID		09419	10937
Ensembl ID		ENSG00000172732	ENSG00000154920
Uniprot IDs		Q53ES5 Q96NY9	Q96AY2
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S	2ZIU 2ZIV 2ZIW 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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