MUS81 and SLX1A

Data Source:
BioGRID (pull down)

		MUS81	SLX1A
Description		MUS81 structure-specific endonuclease subunit	SLX1 homolog A, structure-specific endonuclease subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex	Nucleoplasm Slx1-Slx4 Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity	Protein Binding Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Metal Ion Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Interstrand Cross-link Repair Telomeric D-loop Disassembly Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Breast cancer ( 23535729)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1	6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4
Entrez ID		80198	548593
HPRD ID		09419	18681
Ensembl ID		ENSG00000172732	ENSG00000132207
Uniprot IDs		Q53ES5 Q96NY9	Q9BQ83
PDB IDs		2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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