NRXN3 and HTR6

Data Source:
BioGRID (two hybrid)

		NRXN3	HTR6
Description		neurexin 3	5-hydroxytryptamine receptor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Neuron Cell-cell Adhesion Axon Guidance Learning Adult Behavior Social Behavior Vocalization Behavior	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 26865924 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Bone mineral density (hip) ( 30172743) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrodermal activity ( 25387706) Figural/spatial cognitive ability ( 31620175) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 25673412) JT interval (sulfonylurea treatment interaction) ( 27958378) Medial orbital frontal cortex volume ( 31530798) Normal facial asymmetry (angle of deformation score) ( 30631343) Obesity ( 23563607 21552555) Objective response to lithium treatment in bipolar disorder ( 26503763) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proliferative diabetic retinopathy in type 2 diabetes ( 29739359) Response to antidepressants (symptom improvement) ( 29160301) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Tea consumption ( 31046077) TPE interval (recovery after exercise) ( 32386560) Type 2 diabetes ( 28566273 30054458 30297969) Underweight status ( 25133637) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197 25673412) Waist-hip ratio ( 25673412) Weight ( 28552196)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		8 interacting genes: AFDN CASK DNAJC5 HTR6 NLGN1 NLGN2 NLGN3 PAX4	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		9369	3362
HPRD ID		08989	03066
Ensembl ID		ENSG00000021645	ENSG00000158748
Uniprot IDs		A0A0U1RRJ0 Q9HDB5 Q9Y4C0	P50406
PDB IDs
Enriched GO Terms of Interacting Partners?
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