NRXN3 and AFDN

Data Source:
HPRD (two hybrid)

		NRXN3	AFDN
Description		neurexin 3	afadin, adherens junction formation factor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Neuron Cell-cell Adhesion Axon Guidance Learning Adult Behavior Social Behavior Vocalization Behavior	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 26865924 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Bone mineral density (hip) ( 30172743) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrodermal activity ( 25387706) Figural/spatial cognitive ability ( 31620175) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 25673412) JT interval (sulfonylurea treatment interaction) ( 27958378) Medial orbital frontal cortex volume ( 31530798) Normal facial asymmetry (angle of deformation score) ( 30631343) Obesity ( 23563607 21552555) Objective response to lithium treatment in bipolar disorder ( 26503763) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proliferative diabetic retinopathy in type 2 diabetes ( 29739359) Response to antidepressants (symptom improvement) ( 29160301) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Tea consumption ( 31046077) TPE interval (recovery after exercise) ( 32386560) Type 2 diabetes ( 28566273 30054458 30297969) Underweight status ( 25133637) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197 25673412) Waist-hip ratio ( 25673412) Weight ( 28552196)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		8 interacting genes: AFDN CASK DNAJC5 HTR6 NLGN1 NLGN2 NLGN3 PAX4	37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		9369	4301
HPRD ID		08989	01164
Ensembl ID		ENSG00000021645	ENSG00000130396
Uniprot IDs		A0A0U1RRJ0 Q9HDB5 Q9Y4C0	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs			1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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