BUB3 and BUB1B

Data Source:
HPRD (in vitro, in vivo)

		BUB3	BUB1B
Description		BUB3 mitotic checkpoint protein	BUB1 mitotic checkpoint serine/threonine kinase B
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition	Mitotic Cell Cycle Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Left-handedness ( 32989287) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)	Chronic lymphocytic leukemia ( 28165464 24292274)
Interacting Genes		17 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 RPL37A SUGT1 THRA TOP1 UBA1 WBP4	26 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FBXO7 FZR1 HDAC1 KNL1 MAP3K4 PELI1 PLK1 RIPK3 SNCG TP73 TRIP13
Entrez ID		9184	701
HPRD ID		04761	04176
Ensembl ID		ENSG00000154473	ENSG00000156970
Uniprot IDs		A0A140VJF3 O43684	O60566
PDB IDs			2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?
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