BUB3 and SUGT1

Data Source:
BioGRID (two hybrid)

		BUB3	SUGT1
Description		BUB3 mitotic checkpoint protein	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex	Ubiquitin Ligase Complex Kinetochore Nucleus Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Catabolic Process Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition	Mitotic Cell Cycle Regulation Of Protein Stability Positive Regulation By Host Of Symbiont Catalytic Activity Protein Stabilization
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Body mass index ( 28892062) Left-handedness ( 32989287) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		17 interacting genes: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 RPL37A SUGT1 THRA TOP1 UBA1 WBP4	17 interacting genes: BUB3 CSNK2A1 DSN1 HSP90AA1 HSPA4 MIS12 NR4A1 NSL1 PAXIP1 PHLPP1 PLK1 PMF1 PTGER4 S100A6 S100B S100P SKP1
Entrez ID		9184	10910
HPRD ID		04761	09160
Ensembl ID		ENSG00000154473	ENSG00000165416
Uniprot IDs		A0A140VJF3 O43684	A8K7W3 B4DYC6 Q9Y2Z0
PDB IDs			1RL1
Enriched GO Terms of Interacting Partners?
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