DYRK1B and RANBP9

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, two hybrid, in vitro)

		DYRK1B	RANBP9
Description		dual specificity tyrosine phosphorylation regulated kinase 1B	RAN binding protein 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Nuclear Body
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding Enzyme Binding
	Biological Process	Protein Phosphorylation Myoblast Fusion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Adipose Tissue Development	MAPK Cascade Cytoskeleton Organization Microtubule Nucleation Cell Surface Receptor Signaling Pathway Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways			L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
Drugs		Fostamatinib
Diseases
GWAS		Macular thickness ( 30535121)	Breast cancer ( 29059683 23535729)
Interacting Genes		12 interacting genes: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP	56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5
Entrez ID		9149	10048
HPRD ID		05188	04835
Ensembl ID		ENSG00000105204	ENSG00000010017
Uniprot IDs		A0A024R0I0 A0A024R0J6 A0A024R0M8 Q9Y463	A0A024QZW3 Q96S59
PDB IDs			5JI7 5JI9 5JIU
Enriched GO Terms of Interacting Partners?
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