RANBP9 and AXL

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down)
HPRD (two hybrid)

		RANBP9	AXL
Description		RAN binding protein 9	AXL receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Nuclear Body	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Actin Cytoskeleton Intracellular Membrane-bounded Organelle Receptor Complex Host Cell Surface Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding	Virus Receptor Activity Phosphatidylserine Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Myosin Heavy Chain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	MAPK Cascade Cytoskeleton Organization Microtubule Nucleation Cell Surface Receptor Signaling Pathway Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Neuron Migration Natural Killer Cell Differentiation Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Phagocytosis Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Animal Organ Regeneration Cellular Response To Extracellular Stimulus Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Positive Regulation Of Kinase Activity Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Negative Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Vagina Development Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling	VEGFA-VEGFR2 Pathway
Drugs			Fostamatinib Gilteritinib
Diseases
GWAS		Breast cancer ( 29059683 23535729)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731)
Interacting Genes		56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5	23 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3
Entrez ID		10048	558
HPRD ID		04835	00171
Ensembl ID		ENSG00000010017	ENSG00000167601
Uniprot IDs		A0A024QZW3 Q96S59	M0R0W6 P30530
PDB IDs		5JI7 5JI9 5JIU	2C5D 4RA0 5U6B 5VXZ
Enriched GO Terms of Interacting Partners?
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